INCB086550|CAS 2230911-59-6|PD-L1 inhibitor|DC Chemicals

Cas No.:	2230911-59-6
Chemical Name:	PD-1/PD-L1-IN-8
Synonyms:	PD-1/PD-L1-IN-8
SMILES:	C(O)([C@H]1CN(CC2=CC3N=C(C4C=CC=C(C=4C)C4=C(C(NC5=C6N=CC(CN7CC[C@@H](O)C7)=CC6=CC=N5)=CC=C4)C)OC=3C(C#N)=C2)CC1)=O
Formula:	C₄₁H₃₉N₇O₄
M.Wt:	693.80
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control.

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INCB086550(INCB-086550)