Lycobetaine|cas 72510-04-4|DC Chemicals

Cas No.:	2121-12-2
Chemical Name:	[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium,4,5-dihydro-2-hydroxy-
Synonyms:	[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium,4,5-dihydro-2-hydroxy-;Ungerimine;Lycobetaine
SMILES:	OC1=CC2=C3[N+](=CC4=CC5OCOC=5C=C4C3=C1)CC2
Formula:	C₁₆H₁₂NO₃+
M.Wt:	266.27138
Purity:	>98%, Standard References Grade
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

Ungeremine, a phenanthridine type alkaloid, is extracted of the bulbs of Pancratium Illyricum. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. Ungeremine displays cytotoxic activity towards the 9 cancer cell lines, including drug-sensitive and MDR phenotypes. Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1][2].

References:

[1]. Casu L, et al. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. [2]. Mbaveng A, et al. Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine. 2019 Jul;60:152832.

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Lycobetaine（Ungeremine）