Highly potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B).

Natural anticancer, anti-inflammatory, neuroleptic agent, also having human acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory activities

Novel quantitative chemical probe for live cell labeling and imaging of proteins that are sensitive to redox modifications

TLR2/6 agonist, activating the MyD88 pathway, provoking natural killer (NK) cell activation, increasing co-stimulators CD80/86 and CD40

Selective modulator of plasmodial Hsp70s with antimalarial activity

Potent CB2 receptor inverse agonist

Inhibitor of the amebicidal activity of activated murine macrophages, helping the parasite to survive within the mouse large intestine and increasing the survival of C. elegans exposed to H2O2

Inhibitor of TNF-α, preventing and restoring memory deficits associated with neuropathic pain

Novel reversible monoacylglycerol lipase (MAGL) inhibitor

Polyether ionophore antibiotic, inhibiting proliferation and induces apoptosis in myoblast cells

Potent and selective inhibitor of the induction of cytopathic effect by CHIKV and VEEV

Natural immunomodulator, significantly decreasing TNF-α and IL-10 cytokine production, regulating the NF-κB and MAPK signaling pathways, displaying the strongest antiproliferative effects with IC50 values of 2.84 and 0.95 μM against A431 and HeLa cancer c

Novel inhibitor of the bacterial lipoprotein targeting chaperone, LolA

Novel potent and selective inhibitor of UppS without off-target effects on membrane potential

Novel Peptide Deformylase (PDF) Inhibitor, having inhibitory activity against HeLa, A549 and MCF-7

Partial antagonist of mGlu5

Novel CNS Penetrant ALK2 Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma

Novel potent and selective ALK2 inhibitor, showing high initial brain uptake, including in the region of interest (pons)

Novel selective muscarinic M1 receptor positive allosteric modulator, showed both significant improvement of scopolamine-induced cognitive deficits and severe diarrhea

Novel selective muscarinic M1 receptor positive allosteric modulator, significantly improved scopolamine-induced cognitive deficits without prominent signs of diarrhea at up to 1000 mg/kg in mice

TRPC4/5 channel blocker, exhibiting antidepressant and anxiolytic effects

Novel inhibitor of the transcriptional activity of β-catenin, degrading the expression of β-catenin by stabilizing axin 2 and diminishing downstream proteins levels, including c-Myc and cyclin D1, effectively shrinking tumor xenograft derived from colonic

Inhibitor of cyclooxygenase (COX); Pan partial agonist of PPARγ, PPARα and PPARβ/δ

Inhibitor of viral replication, especially useful in the treatment of the Herpes family of viruses which includes Herpes Simplex 1 and 2 , EBV , CMV and Varicella.

Natural Potent Marine-Derived Elastase Inhibitor

Nove fluorescent probe for highly sensitive monitoring drug induced lysosomal pH value changes, exhibiting good biological compatibility, low cytotoxicity and high resistance to photobleaching

Novel F1F0-ATPase modulator, significantly decreasing M2 glutamate and increasing M4 glutamate

Novel inhibitor of the type I transforming growth factor beta receptor (TβRI)

Prodrug of LY354740, highly selective and potent agonist of group II mGlu receptors (mGluR2)

Novel competitive GLUK5 receptor antagonist