Novel antibiofilm coating, covalently bindng to a titanium implant surface (LC0024-Ti)

Neurotoxic amino acid

Prodrug of LB30870 as potent, orally active, selective and direct thrombin inhibitor

Potent, orally active, selective and direct thrombin inhibitor

Natural inhibitor of the proliferation of sensitive and resistant human cancer cell lines and this inhibitory activity is strongly increased in the presence of laxaphycin A

Natural antifungal and cytotoxic agent

Microtubule stabilzer, potently inhibiting cellular proliferation in cancer cell lines

Disruptor of microfilament-mediated processes

Natural F508del-CFTR trafficking corrector, targeting poly(ADP-ribose) polymerase (PARP)

Natural F508del-CFTR corrector, inhibiting both PARP-3 and -16, regulating the activity of the unfolded protein response activator inositol-requiring enzyme (IRE-1) via modulation of the level of its ribosylation by PARP-16

Novel Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitor

Novel orally active IKK2 inhibitor

Novel IKK-β inhibitor, reducing the secretion of TNF-α, IL-1β, IL-6, IL-12, IFN-γ and increased secretion of IL-10, protecting gastrointestinal homeostasis

Novel Adenosine A2a Receptor Agonist, Attenuating the Progression of Monocrotaline-induced Pulmonary Hypertension

Novel adenosine receptor agonist, inducing relaxation of corpus cavernosum; Novel selective phosphodiesterase-​4 (PDE4) inhibitor associated with anti-​TNF-​α properties

Novel dual TRPV1 antagonist and TNF-alpha production inhibitor

Lipopeptide antibiotic with activity against a range of Gram-positive bacteria including drug-resistant pathogens

Natural fungal phytotoxin, activating the plant jasmonic acid pathway

Novel, potent and selective CRTh2 antagonist

Potent inhibitor of histone deacetylase

Novel Modulator of autoimmune demyelination

Novel Peptide Deformylase Inhibitor against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus

Glutamate receptor antagonist and radical scavenging agent

Top1mt inhibitor, targeting mitochondrial DNA

Adenosine A1 receptor antagonist, reducing allergic responses to house dust mite in an allergic rabbit model of asthma, improving survival and protecting the kidney in a rat model of cecal ligation and puncture induced sepsis, also improving survival and

The first organ-selective thyromimetic, lowering plasma low density lipoprotein (LDL) cholesterol and raising plasma high density lipoprotein (HDL) cholesterol levels

Novel inhibitor of HIV-1 and SIV integrase

Chemically-modified forskolin with greater stability and water solubility than the parent compound

Novel HIV-1 integrase strand transfer inhibitor (INSTI), stabilizing an integrase-single blunt-ended DNA complex

Potent and selective agonist of the human beta3 adrenergic receptor