Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root. It takes its name from its emetic properties. Emetine protects mice from enterovirus infection by inhibiting viral translation. Emetine Synergizes with Cisplatin to Enhance Anti-Cancer Efficacy against Lung Cancer Cells. Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/β?catenin signaling. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.

alpha-Cypermethrin is a synthetic pyrethroid pesticide.

Hadacidin is an inhibitor of AMP synthesis. Hadacidin and hadacidin analogues have anticancer activity and activity against adenylosuccinate synthetase.

alpha-Artemether is a Quinghaosu derivative which shows antimalarial and antifungal activity.

AM 6201, also known as Reductiomycin, is an alkaloid originally derived from Streptomyces xanthochromogenus that has been shown to exhibit antitumor activity against Ehrlich ascites carcinomas in mice.

PEG5-Ms is a PEG Linker.

6-Maleimidocaproic acid PFP ester is a PEG Linker.

4-((2,5-Dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Mal-PEG2-NH-Boc is a PEG derivative containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Mal-PEG2-amine TFA salt is a PEG derivative containing a maleimide group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

SPDP acid is a non-PEG crosslinker.

N1,N1'-(1,4-phenylenebis(methylene))bis(N1-(2-aminoethyl)ethane-1,2-diamine) HCl salt

Tetraethyl butane-1,4-diylbis(phosphonate) is a non-PEG crosslinker. Crosslinkers may be useful in the development of antibody drugconjugates.

m-PEG7-4-nitrophenyl carbonate is a PEG Linker

m-PEG8-thiol is a PEG derivative containing a thiol group. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.

m-PEG3-acid chloride is a PEG derivative containing a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

PEG13 is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.

PEG12 is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.

THP-PEG8-Tos is a PEG linker. The PEG linker contains 7 units of ethylene glycol.

THP-PEG9 is a PEG Linker.

Hydroxy-PEG1-t-butyl ester is a PEG derivative containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Hydroxy-PEG4-CH2CO2H, sodium salt, is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Fmoc-NH-PEG11-CH2COOH is a PEG derivative containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.

Bromo-PEG5-bromide is a PEG derivative containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

t-Boc-N-Amido-PEG3-azide is a PEG derivative containing an azide group and Boc-protected amino group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. PEG Linkers may be useful in the development of antibody drug conjugates.

Bis-PEG2-NHS ester is a PEG derivative containing two NHS ester groups. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. PEG Linkers may be useful in the development of antibody drug conjugates (ADCs).

Bis-PEG1-NHS ester is a PEG derivative containing two NHS ester groups. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. PEG Linkers may be useful in the development of antibody drug conjugates.

Biotin-PEG4-amine is a PEG derivative containing a biotin group and a terminal primary amine group. The amine group can be coupled to carboxyl groups or 5'phosphate groups to form stable amide bonds. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules. Therefore, PEG Linkers can be useful in the development of antibody drug conjugates and drug delivery methods.

Amino-PEG4-amine is a PEG derivative containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.