Selective D2 dopamine receptor antagonist

Antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR)

Potent Inhibitor of Plasmodium FK506 Binding Protein 35 (FKBD35), also act as a HIV inhibitor

5-HT2 antagonist

Novel fibroblast growth factor receptor modulator for treating neurodegenerative diseases

D2 selective dopamine agonist, showing anxiolytic and anti-parkinsonian activities

Novel, potent, selective, and competitive antagonist of LTD4 and LTE4

Peripheral vasodilator

Neuroprotective agent, alleviating stroke-induced neuroinflammation

Novel inhibitor of RhoG-hepcidin uptake

β-Lactam antibiotic against multi-drug resistant pathogens

Antibacterial, inhibiting bacterial folic acid synthesis by competing with para amino benzoic acid

Novel inhibitor of airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease (COPD)

Novel potent inhibitor of osteoclastogenesis, suppressing both equilibrative nucleoside transporters and concentrative nucleoside transporters

Fluorescent substrate which can be hydrolyzed by the proteasome to release free AMC and the fluorescence of which is proportional to the proteasome activity

Natural immunosuppressive agent, effectively blocking T cell proliferation and survival while profoundly inhibiting pro-inflammatory IFNγ and IL-17 production by fully differentiated effector Th1 and Th17 cells, also acting as an estrogen receptor antagon

Novel potent and selective inhibitor of the cellular PDGF receptor kinase and PDGF receptor-induced cell proliferation

Agonist of TRPV1

Sunitinib analog, acting as a potential inhibitor for nucleoside diphosphate kinase (NDK) from Leishmania major (LmNDK)

Potent c-MET inhibitor

Novel potent c-MET inhibitor

Novel dual Inhibitor of repair enzymes 8-oxoguanine DNA glycosylase (OGG1) and human MutT Homolog 1 (NUDT1 or MTH1), increasing sensitivity of tumor cells to oxidative stress

Novel Nonsteroidal Inhibitor of Carbonic Anhydrase IX

Inhibitor of 17β-hydroxysteroid dehydrogenases (17β-HSDs)

Novel agonist of the tissue-protective erythropoietin (EPO) receptor, increasing FXN expression and EPOR phosphorylation

The first nonpeptidyl, selective activator of the tissue-protective EPOR/CD131 receptor

Antibiotic, being used as an antineoplastic agent and to induce diabetes in experimental animals

Metablite of the Streptomyces antibiotics streptothricin and streptolin

Potent natural modulator of human Toll-like receptor 7 (TLR7)

Novel activator of cellular ATG4B activity