Novel dual H1 and H3 receptor antagonist with a long duration of action

Potent inhibitor of AKT kinase

Novel potent EchA6 inhibitor

Novel allosteric HIV-1 integrase (IN) inhibitor, disrupting formation of mature HIV particles

Glutamate receptor antagonist and radical scavenging agent

Novel high potent and selective stabilizer of the MYC G-quadruplex (G4)

Potent and selective inhibitor of HIV-1 protease, effectively inhibiting protease mutants with amino acid insertions, also inhibiting major aspartyl peptidase 1 (May1), a secreted Cryptococcus neoformans protease

Novel oral prodrug of GS-441524, inhibiting SARS-CoV-2, including variants of concern (VOC) in cell culture and human airway epithelium organoids

Novel Inhibitor of Hepatitis C Viral Infectivity

Novel potent inhibitor of feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies

Novel allosteric inhibitor of respiratory syncytial virus (RSV)

Novel β-Secretase BACE1 Inhibitor, reversing memory impairments and rescuing age-related cognitive decline

Novel CCR5 inhibitor, inhibiting the replication of wild-type R5-HIV-1

Novel, potent, and selective G protein-coupled receptor kinase 6 (GRK6) inhibitor with an IC50 value of 6 nM against GRK6 and selectivity against a panel of 85 kinases

Novel potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor

Natural Potent Inhibitor for Glioblastoma Stem Cell via Targeting RHOA and PI3K/AKT

Novel oral specific TRPV1 antagonist, decreasing bladder overactivity and noxious bladder input in cystitis animal models

Novel orally available, potent and selective inhibitor of Transient Receptor Potential Ankyrin 1 (TRPA1) with IC50 value less than 10 nM

Natural blocker of the voltage-gated sodium channels located in the cell membrane of neurons

Novel Nrf2 modulator via a thus far uncharacterized mechanism

Potent 5HT3 antagonist

Bacterial siderophore with a diazeniumdiolate ligand system

5-HT3 receptor antagonist

5-HT1B/5-HT1D serotonin receptor antagonist

Novel inhibitor of the EGFr and C-erbB-2.

Selective and brain penetrant NK1-receptor antagonist

Negative control for GI181771X

Potent TrkA kinase inhibitor

Novel dual G-quadruplex/i-motif binder, binding to and stabilizing both G-quadruplex and i-motif, being effective in both oncogene replication and transcription

Novel high affinity, potent, and selective stabilizer of the MYC G-quadruplex (G4)., inducing cytotoxicity with corresponding decreased MYC mRNA and altering protein binding to the NHE III1 region