Novel CK2 inhibitor, targeting an allosteric pocket, exhibiting an IC50 of 3.4 μM against purified CK2α in combination with a favorable selectivity profile

Novel potent CK2 inhibitor

Potent, reversible, and ATP-competitive inhibitor of casein kinase-2 (CK2)

Novel selective allosteric modulator of the protein kinase CK2, inducing apoptosis and cell death in 786-O renal cell carcinoma cells (EC50 = 5 µM) and inhibiting STAT3 activation even more potently than the ATP-competitive drug candidate CX-4945

Novel potent PfNDH2 inhibitor

Novel CK2 inhibitor, showing potent CSC inhibitory effects in A549 cells

Long-lasting stimulator of the production of growth hormone (GH) from the pituitary gland

Stimulator of the production of growth hormone (GH) from the pituitary gland

Novel inhibitor of STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain

Anti-HIF-1alpha agent, inhibiting HIF-1alpha and cellular VEGF proteins

Novel non-ATP competitive allosteric inhibitor of Aurora B kinase, binding in the allosteric site F

SecA inhibitor, showing antiprotozoal, antibacterial and antifungal effects, inhibiting post-translational protein transport into the endoplasmic reticulum. also Inhibiting ATP-dependant translocation of precursor proteins acrossing a bacterial cell membr

Novel potent muscarinic antagonist wirh antimuscarinic antidepressant-like activities, showing modest affinity across the mAChRs when compared to L-687306 and scopolamine

Potent and competitive antagonist at the human D3 receptor

Biological Active Reagents

Novel Cell-Permeable STAT3 Inhibitor, targeting the SH2 domain

Polo-like kinase 1 (Plk1) inhibitor

Negative control for VZ185

Novel, natural auxin efflux inhibitor, promoting lateral root formation

JBP923 analog, exerting potent therapeutic effect on inflammatory bowel disease (IBD)

Potent inhibitor of MRSA PK

Positive modulator of GABA A receptors

Non-Specific Anticoagulant Reversal Agent

Broad-spectrum antimicrobial carboxyfluoroquinoline, interfering with the bacterial DNA gyrase, inhibiting the DNA synthesis, and preventing bacterial cell growth

Novel modulator of SLC6A19, robustly, selectively, and reproducibly inhibiting SLC6A19

Agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors

5-HT2 antagonist

ß-Adrenergic agonist

Noncompetitive inhibitor of Candida albicans growth and activity of (1-3)-beta-glucan synthase

Cell permeable caged inositol triphosphate, promoting Ca2+-release from internal stores under UV photolysis