113-O12B|Ionizable Lipid for LNP

Cas No.:	2803699-72-9
Chemical Name:	113-O12B
Synonyms:	113O12B， 113 O12B
SMILES:	N(CCC(OCCSSCCCCCCCC)=O)(CCC(=O)OCCSSCCCCCCCC)CCN(C)CCN(CCC(=O)OCCSSCCCCCCCC)CCC(=O)OCCSSCCCCCCCC
Formula:	C₅₇H₁₁₁N₃O₈S₈
M.Wt:	1223.03
Purity:	>95%
Sotrage:	-20
Publication:	Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+T cell response. PNAS, (2022), 119, 34, e2207841119.

Cat. No.	Product name	Field of application
DC53130	93-O17S	93-O17S is an imidazole-based synthetic lipidoid for in vivo mRNA delivery. Lipid nanoparticles (LNPs) with 93-O17S promotes both the cross-presentation of tumor antigens and the intracellular delivery of cGAMP (STING agonist).
DC60495	9322-O16B	9322-O16B is a lipidoid for the efficient delivery of antiCD19 mRNA CAR to murine primary macrophages. LNP 9322-O16B is more efficient than delivery with lipofectamine 2000 (LPF2K) or MC3.
DC80065	113-O12B	113-O12B is a disulfide bond-containing ionizable cationic lipidoid. 113-O12B LNP, an LN-targeting LNP delivery system, is developed for a mRNA cancer vaccine. The 113-O12B/mRNA shows enhanced expression in APCs compared with ALC-0315/mRNA, indicating the LN-specific targeting ability.