BI-0252|BI 0252;BI0252

Cas No.:	1818291-27-8
Chemical Name:	4-[(3S,3'S,3'aS,5'R,6'aS)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-2-oxo-1,2,3',3'a,4',5',6',6'a-octahydro-1'H-spiro[indole-3,2'-pyrrolo[3,2-b]pyrrole]-5'-yl]benzoic acid
Synonyms:	BI 0252;BI0252
SMILES:	C(O)(=O)C1=CC=C([C@H]2N[C@@]([H])3[C@@H](C4=CC=CC(Cl)=C4F)[C@](N(CC4CC4)[C@]3([H])C2)2C3=C(NC2=O)C=C(Cl)C=C3)C=C1
Formula:	C₃₀H₂₆Cl₂FN₃O₃
M.Wt:	566.45
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM; shows in vivo efficacy in a SJSA-1 xenograft model.

Cat. No.	Product name	Field of application
DC47576	Sanggenol L	Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells. Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p
DC47288	Teprasiran	Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI).
DC46420	MDM2-IN-21	MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.
DC42468	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride	p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an of the interaction between p53 and MDM2 proteins.
DC42467	p53 and MDM2 proteins-interaction-inhibitor (chiral)	p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an of the interaction between p53 and MDM2 proteins.
DC42132	Triglycidyl isocyanurate	Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.
DC40025	Milademetan tosylate hydrate	Milademetan (DS-3032) tosylate hydrate is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) tosylate hydrate induces G1 cell cycle arrest, senescence and apoptosis.
DC28687	MDM2-IN-1	MDM2-IN-1 (Compound 30) is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration.
DC28442	Pifithrin-α, p-Nitro, Cyclic	Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue.
DC8455	Nutlin-3b	Nutlin-3b is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (−)-nutlin-3, demonstrating an IC50 value of 13.6 µM.