NG 52 (Compound 52)|cell cycle kinase inhibitor

Cas No.:	212779-48-1
Chemical Name:	2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
Synonyms:	NG52, Compound52,NG-52,Compound-52
SMILES:	CC(C)N1C=NC2=C1N=C(N=C2NC3=CC(=CC=C3)Cl)NCCO
Formula:	C₁₆H₁₉ClN₆O
M.Wt:	346.81
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).Compound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).

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