PF00835231|CAS 870153-29-0|DC Chemicals

Cas No.:	870153-29-0
Chemical Name:	PF00835231
Synonyms:	Compound 5h (SARS-CoV-2 inhibitor) ;PF00835231;PF-00835231;PF 00835231
SMILES:	COc1c2c([nH]c(c2)C(N[C@H](C(N[C@H](C(c2sc3c(cccc3)n2)=O)C[C@H]2C(=O)NCC2)=O)CC(C)C)=O)ccc1
Formula:	C₃₀H₃₃N₅O₅S
M.Wt:	575.68
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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DC31006	WP1122	WP-1122(WP 1122) is a candidate drug to treat SARS-COV-2(COVID-19) .2-DG completely prevented SARS-CoV–2 replication in Caco–2 cells. Glycolysis is a process by which cells convert glucose into energy and infected (host) cells are induced by viruses to dramatically increase their dependence on glycolysis. WP1122 is a prodrug of 2-DG whereby chemical elements are added to 2-DG to improve its delivery in vivo.
DC28041	BIOTIN-PEG4-SBP1(spike-binding peptide 1)	Biotin modification of SBP1.SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein. SBP1 specifically binds SARS-CoV-2-RBD with low nanomolar affinity. SBP1 to the RBD was determined to be 47 nM with the average Kon = 4.69104M-1S-1 and Koff=2.210-3.The interaction between SBP1 and the RBD of SARS-CoV-2 spike protein was validated by bio-layer interferometry. The KD, derived from protein association and dissociation kinetics, was found to be 47 nM after averaging the fitting values at different protein concentrations. The amino acid sequence of SBP1 is entirely derived from human ACE2 and should be recognized as endogenous by the human immune system. This feature could be highly beneficial in later stages of pre-clinical development.
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DC50035	PF00835231	PF00835231(SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 µM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 µM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.