Novel adenosine A2A receptor (A2AR) antagonist

Novel potent and orally active adenosine kinase inhibitor

Novel potassium channel opener, more potent enantiomer

Negative control for A-192621

Selective adenosine kinase (AK) inhibitor

Novel blocker of the activation of the TRPV1 channel by capsaicin, inducing hypothermia involving tail-skin, vasodilation at thermoneutrality, decreasing body temperature

Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy

Fluorogenic A9 Peptide Probe, Interacting with Its Receptor Model HER2-DIVMP

Selective TRPV1 antagonist

Natural IDO1 inhibitor, cytotoxic and antiplasmodial agent

Novel natural anticancer agent, exhibiting potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition

Novel, potent, mutant-selective BET bromodomain inhibitor, showing >100-fold selectivity for the L/V mutant over wild-type and excellent DMPK properties

Inhibitor of cyclin-dependent kinases

Novel ATP-competitive GSK-3ß inhibitor, exhibiting potent antiproliferative activity

Endogenous peripheral TRPV1 ligand

Dual human A2a antagonist/MAO-B inhibitor

Potent and selective activator of protein kinase A (PKA) type I and II

Potent activator of cGMP-dependent protein kinase Ia, Ib and type II as well as of cGMP- gated ion channels

Unique cytoprotective mediator, inhibiting oxidative stress; Novel probe of the protein S-guanylation

Antitumor agent, displaying cytotoxicity against the human cancer cell lines, including MDA231, T-47D, Hs578t, SaoS2, K562, SKHep1,and Hep3B

Novel inhibitor of nitric oxide formation in macrophages independent of effects on TNF

Specific non-nucleoside RT inhibitor (NNRTI) of HIV-1 RT

Inhibitor of RNA synthesis

Building Block

Potent and selective inhibitor of NTPDase1

Potent and selective inhibitor of NTPDase1

Potent and selective inhibitor of NTPDase1

Building block for syntheses of 8-BuS-AMP, ADP, ATP, and c-AMP

Novel activator of cAMP-dependent protein kinase (PKA) with high selectivity for site B-I of PKA

Carcinogenic adduct, covalently binding DNA bases and promoting mutagenesis near the adduct site