Broad spectrum antibiotic used in the therapy of drug resistant tuberculosis as a second line agent

Reverse-transcriptase_inhibitor>Non-nucleoside reverse transcriptase inhibitor

Novel self-assembling lysine-rich cationic amphipathic peptide (CAP)

Natural cannabinoid precursor

Natural cannabinoid precursor

Novel destabilizer of CAND1-Cullin1 interaction, inducing a p53-stress response pathway

Transmembrane protease serine 2 (TMPRSS2) inhibitor for the treatment of chronic pancreatitis and postoperative gastric reflux, blocking SARS-CoV-2 replication in TMPRSS2-expressing human cells

Ionophore highly selective for Ca , potentiating responses to NMDA but not quisqualate

Dual inhibitor of fibroblast growth factors (FGF) and vascular endothelial growth factor (VEGF) ; Anti-angiogenic

Novel inhibitor of p110

Effective inhibitor of the carbonic anhydrase (CA) from Trypanosoma cruzi (TcCA)

Potent agonist at thyroid hormone receptor (TR)

Novel photocaged ERK1/2 inhibitor as a light-controlled anticancer agent

Potent, selective class B inhibitor of calcium-activated chloride channels (CaCCs)

Novel selective CaBdf1 BD2 inhibitor

Novel inhibitor of CaBdf1 BD1 with low-micromolar affinity and three- to fivefold selectivity relative to human Brd4 BD1

Novel selective CaBdf1 BD1 inhibitor

Novel specific inhibitor of cathepsin L, effectively inhibiting degradation of LC3-II and GABARAP

Potent and selective inhibitor of cathepsin B

Selective inhibitor of hCA IX and hCA XII

Novel covalent cross-linker to the SARS-CoV-2 frameshifting element (FSE), directly targeting engagement of the SARS-CoV-2 FSE in cells, dose dependently reducing frameshifting in cells expressing the SARS-CoV-2 FSE, with no significant effect on frameshi

Novel potent inhibitor of botulinum neurotoxin serotype E (BoNT/E)

Inducer of mast cell degranulation

The first C3b-binding complement inhibitor, inhibiting the formation of the membrane attack complex (MAC) by preventing cleavage of C5

First-In-Class Inhibitor of the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor, Affecting the Viability and Toxin Release of Streptococcus pneumoniae

Novel selective activator for TREK, against other two-pore domain K (K2P) channels

Novel multi-functional resveratrol derivative for the treatment of atrial fibrillation

FPP analogue, bearing an alkyne group to allow for post-prenylation protein labeling

Novel broad-spectrum intracellular targeting antibacterial agent, interacting with the 70S ribosome of E. coli and inhibiting its protein synthesis, demonstrating superior clearance of bacteria from the spleen, liver, and kidneys of mice, infected with S.

Novel broad-spectrum intracellular targeting antibacterial agent, interacting with the 70S ribosome of E. coli and inhibiting its protein synthesis, demonstrating superior clearance of bacteria from the spleen, liver, and kidneys of mice, infected with S.