LJ570|CAS 2252488-69-8|DC Chemicals

Cas No.:	2252488-69-8
Chemical Name:	(S)-3-([1,1'-biphenyl]-4-yl)-2-([1,1'-biphenyl]-4-yloxy)propanoic acid
Synonyms:	LJ570; LJ-570; LJ 570.
SMILES:	O=C([C@H](CC1C=CC(C2C=CC=CC=2)=CC=1)OC1C=CC(C2C=CC=CC=2)=CC=1)O
Formula:	C₂₇H₂₂O₃
M.Wt:	394.46
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation Antonio Laghezza, Luca Piemontese, Carmen Cerchia, Roberta Montanari, Davide Capelli, Marco Giudici, Maurizio Crestani, Paolo Tortorella, Franck Peiretti, Giorgio Pochetti, Antonio Lavecchia, and Fulvio Loiodice Publication Date (Web): September 10, 2018 (Article) DOI: 10.1021/acs.jmedchem.8b00835

Description:	LJ570 is a PPARα/PPARγ dual agonist with EC50s of 1.05 and 0.12 μM, respectively[1].
Target:	PPARα:1.05 μM (EC50) PPARγ:0.12 μM (EC50)
References:	[1]. Laghezza A, et al. Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. J Med Chem. 2018 Sep 27;61(18):8282-8298

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