TSHR antagonist S37b|CAS 2143452-22-4|DC Chemicals

Cas No.:	2143452-22-4
Chemical Name:	TSHR antagonist S37b
Synonyms:	TSHR antagonist S37b;5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
SMILES:	C1(=O)[C@]2([H])[C@@]([H])([C@@]3([H])C[C@]2([H])[C@]2([H])[C@@H](C4=CC=CC=C4)C4SC(=O)NC=4S[C@]32[H])C(=O)N1C1=CC=CC=C1
Formula:	C₂₅H₂₀N₂O₃S₂
M.Wt:	460.57
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

Cat. No.	Product name	Field of application
DC73510	Org 274179-0	Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line.
DC40415	TSHR antagonist S37b	TSHR antagonist S37b is an enantiomer of TSHR antagonist S37a, shows only a minor effect for TSHR inhibition. TSHR antagonist S37b can be used for the research of thyroid function.
DC73511	SYD5115 (SYD-5115, SYD 5115)	SYD5115 (SYD-5115) is a potent, selective and orally bioavailable thyrotropin receptor (TSH-R) antagonist with IC50 of 48 and 62 nM for rTSHR and hTSHR, respectively.