Ezatiostat(TER199; TLK199)|cas 168682-53-9|DC Chemicals|Price|Buy

Cas No.:	168682-53-9
Chemical Name:	Ezatiostat
Synonyms:	TLK199; TLK-199; TLK 199; Ezatiostat; Brand name: TELINTRA
SMILES:	O=C(OCC)[C@@H](C1=CC=CC=C1)NC([C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O
Formula:	C₂₇H₃₅N₃O₆S
M.Wt:	529.648
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
In Vitro:	Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

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