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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC76445 ABD459
ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders.
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DC76444 8β-Hydroxy-exo-THC
8β-Hydroxy-exo-THC is a cannabinoid ether analogue with a weaker affinity for receptor sites, with an IC50 of 1.2 μM.
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DC76443 6',7'-Epoxy cannabigerol
6',7'-Epoxy cannabigerol is a phytocannabinoid metabolite.
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DC76442 5'-Hydroxy-9(S)-hexahydrocannabinol
5'-Hydroxy-9(S)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
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DC76441 5'-Hydroxy-9(R)-hexahydrocannabinol
5'-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite.
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DC76440 5-Fluoro THJ
5-Fluoro THJ is a derivative of THJ-018. THJ-018 is a synthetic cannabinoid.
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DC76439 3-CAF
3-CAF is a synthetic cannabinoid featuring a 3-carboxylate-indazole structure.
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DC76438 2-Fluoro QMPSB
2-Fluoro QMPSB (QMDFPSB) is structurally similar to known synthetic cannabinoids.
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DC76437 11-Hydroxy-9(S)-hexahydrocannabinol
11-Hydroxy-9(S)-hexahydrocannabinol is a phytocannabinoid metabolite.
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DC76436 11-Hydroxy-9(R)-hexahydrocannabinol
11-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite.
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DC76435 10α-Hydroxy-Δ8-THC
10α-Hydroxy-Δ8-THC (10α-Hydroxy-Δ8-tetrahydrocannabinol) is a phytocannabinoid.
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DC76434 (±)-CBCP
(±)-CBCP ((±)-Cannabichromephorol) is structurally similar to known phytocannabinoids.
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DC76433 (±)-Cannabichromeorcin
(±)-Cannabichromeorcin is a cannabinoid.
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DC76432 (±)-Cannabichromebutolic acid
(±)-Cannabichromebutolic acid is structurally similar to known phytocannabinoids.
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DC76431 (±)-9α-Hydroxy hexahydrocannabinol
(±)-9α-Hydroxy hexahydrocannabinol ((±)-9α-Hydroxy HHC) is structurally similar to known phytocannabinoids.
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DC76430 (±)-8'-Hydroxy cannabichromene
8'-Hydroxy cannabichromene is a phytocannabinoid metabolite.
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DC76429 (±)-6',7'-Epoxy cannabichromene
(±)-6',7'-Epoxy cannabichromene is a phytocannabinoid metabolite.
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DC76428 (±)-6',7'-Dihydroxy cannabichromene
(±)-6',7'-Dihydroxy cannabichromene is a phytocannabinoid metabolite.
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DC76427 (-)-7-Nor-7-carboxy cannabidiol
(-)-7-Nor-7-carboxy cannabidiol is a phytocannabinoid metabolite. (-)-7-Nor-7-carboxy cannabidiol is a metabolite of Cannabidiol.
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DC76426 BI-113823
BI-113823 is an orally active and selective bradykinin B1 receptor antagonist. BI-113823 can reduce complete Freund's adjuvant.
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DC76425 PD 165929
PD 165929 is a high affinity and competitive non-peptide neuromedin-B (NMB) receptor selective antagonist (Ki: 6.3 nM; IC50: 150 nM for rat NMB receptor).
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DC76424 AMTG-DA1
AMTG-DA1 is a Gastrin-releasing peptide receptor (GRPR) ligand. AMTG-DA1 can be used in the study of cancer.
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DC76423 KR31173
KR31173 is an AT1 antagonist with an IC50 of 3.27  nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice.
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DC76422 Zometapine
Zometapine (CI-781) is a pyrazolodiazepine derivative. Zometapine can be used in antidepressant research.
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DC76421 TD-5471
TD-5471 is a potent and selective full agonist of the human β2-adrenoceptor.
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DC76420 N-Nitroso clonidine
N-Nitroso clonidine, a nitrosamine, is a metabolite of Clonidine.
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DC76419 N-Methylindan-2-amine hydrochloride
N-Methylindan-2-amine hydrochloride (compound 3b) is an N-alkylated congener of phenylethylamine that increases hot plate reaction time in mice without inducing dopaminergic effects. N-Methylindan-2-amine hydrochloride can be used to study central noradrenergic mechanisms.
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DC76418 MK-761 TFA
MK-761 TFA is a potent and orally active β2-adrenergic blocker. MK-761 TFA shows antihypertensive and positive inotropic effects. MK-761 TFA shows vasodilating properties.
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DC76417 Levomedetomidine hydrochloride
Levomedetomidine hydrochloride is an isomer of Medetomidine.
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DC76416 KUM 32
KUM 32 is a potent antagonist of epinephrine-induced platelet aggregation. KUM 32 is an adenylate cyclase activity inhibitor. KUM 32 binds to the alpha 2 adrenergic receptor of human platelets.
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