Saclofen|GABAB receptor antagonist|DC Chemicals

Cas No.:	125464-42-8
Chemical Name:	3-AMino-2-(4-chlorophenyl)propane-1-sulfonic acid
Synonyms:	Saclofen
SMILES:	ClC1=CC=C(C(CN)CS(O)(=O)=O)C=C1
Formula:	C₉H₁₂ClNO₃S
M.Wt:	249.71
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Saclofen is a competitive antagonist of the GABAB receptor with an IC50 of 7.8 μM. Saclofen can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain[1].

Cat. No.	Product name	Field of application
DC48191	Cipepofol	Cipepofol (HSK3486), a sedative-hypnotic agent, is a gamma-aminobutyric acid (GABA) receptor potentiator.
DC9958	U 93631	U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.
DC8896	Tiagabine hydrochloride	Tiagabine(NO328) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
DC8099	Saclofen	Saclofen is a selective GABAB antagonist.
DC10578	rac BHFF	Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo.
DC10113	Pipequaline	Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
DC11267	ONO-8590580	ONO-8590580 is a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models.
DC8083	NS11394	NS11394 possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
DC8642	Lorediplon	Lorediplon is a new GABAA modulator Drug for treatment of insomnia.
DC10853	LAU159	LAU159 is a novelα6β3γ2 GABAA receptor inhibitor.