Partial agonist at dopamine D2 and serotonin 1A receptors

Novel inhibitor of the TGF-β pathway, blocking the epithelial to mesenchymal transition

GABAA receptor antagonist

Antilipidemic agent

Triple reuptake inhibitor (TRI)

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

Novel, highly selective and potent irreversible BTK inhibitor

Novel nonpeptide angiotensin II receptor antagonist

Novel potent, highly selective, and orally bioavailable CATHEPSIN C (CTSC, CatC) inhibitor

Non-ATP competitive inhibitor of JNK, targeting the JNK-JIP interaction

Novel RORγ antagonist for the treatment of autoimmune diseases

Novel highly potent dual inhibitor of BRD9/BRD7

Novel potent and selective ATP-competitive inhibitor of glycogen synthase kinase (GSK-3), targeting both isoforms GSK-3α and GSK-3β

Novel potent and selective inhibitor of Alk5 (TGFßR1), blocking the phosphorylation of Smad2 and Smad3 in HaCaT cells

Novel inhibitor of HIV replication, preventing the formation of the capsid core structure that encapsulates the viral genome and its associated enzymes, reversing transcriptase and integrase

Novel highly selective, soluble and cellular permeable inhibitor of the P. falciparum protease dipeptidyl aminopeptidase 1 (DPAP1)

Novel potent inhibitor of human chymase with >100 fold selectivity against Cathepsin G

Novel PROTAC (proteolysis-targeting chimera) as a PTK2 protein degerader

Novel photoactivatable form of serotonin

Reactive dark quencher used in a variety of Fluorescence Resonance Energy Transfer (FRET) DNA detection probe.

Cell-permeable apoptosis inducer, specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family

The first small-molecule substrate identified with high selectivity for BGT1 over the three other GAT subtypes; M1 muscarinic agonist

Novel dual inhibitor of norepinephrine transporter (NET) function and thyrointegrin αvβ3 receptor

Novel Aldose_reductase_inhibitor>aldose reductase (ALR2) inhibitor

Potent inhibitor of centrosomal clustering in malignant cells

Novel potent and selective inhibitor of kynurenine aminotransferase II

Novel probe for neurofibrillary tangles (tau fibrils)

Novel HIF Prolyl Hydrolase Inhibitor, preventing colonic inflammation and fibrosis in murine models of inflammatory bowel disease

Novel BET inhibitor, selectively targeting BRD4-BD1 bromodomain

Novel Dual BET-BRD7/9 Bromodomain Inhibitor, showing a strong antiproliferative effect on various cancer cell lines that could not be observed for BD family selective inhibitors