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Micafungin sodium

  Cat. No.:  DCAPI1514   Featured
Chemical Structure
208538-73-2
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More than 5000 active chemicals with high quality for research!
Field of application
Micafungin(FK463) is an echinocandin antifungal drug, Micafungin inhibits the production of beta-1,3-glucan, an essential component of fungal cell walls.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 208538-73-2
Chemical Name: Micafungin sodium
Synonyms: Micafungin Sodium;FK 463;Pneumocandin A0, 1-​[(4R,​5R)​-​4,​5-​dihydroxy-​N2-​[4-​[5-​[4-​(pentyloxy)​phenyl]​-​3-​isoxazolyl]​benzoyl]​-​L-​ornithine]​-​4-​[(4S)​-​4-​hydroxy-​4-​[4-​hydroxy-​3-​(sulfooxy)​phenyl]​-​L-​threo;Caspofungin Acetate;L743873;MK0991;1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 sodium salt;Mycamine;Sodium;[5-[(1R,2R)-2-[(3R,6R,9R,11S,15R,18R,20S,21S,24R,25R,26R)-3-[(1S)-3-amino-1-hydroxy-3-oxoprop
SMILES: [Na+].CCCCCOc1ccc(cc1)c2onc(c2)c3ccc(cc3)C(=O)N[C@H]4C[C@@H](O)[C@@H](O)NC(=O)[C@@H]5[C@@H](O)[C@@H](C)CN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6C[C@@H](O)CN6C(=O)[C@@H](NC4=O)[C@@H](C)O)[C@H](O)[C@@H](O)c7ccc(O)c(OS(=O)(=O)[O-])c7)[C@H](O)CC(=O)N
Formula: C56N9O23SH71
M.Wt: 1270.274
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Micafungin sodium (FK 463) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.
In Vivo: Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals[2].
In Vitro: Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts[1]. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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