| DC11936 |
TAK-915 |
A highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
|
| DC11878 |
AMG-579 |
AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM. |
|
| DC9935 |
Basmisanil(RG1662)
Featured
|
Basmisanil is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. |
|
| DC8882 |
Bitopertin
Featured
|
Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
|
| DC9067 |
Clozapine |
Clozapine(HF 1854) is a 5-HT2A/2C and dopamine receptor blocker with Ki values of 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively. |
|
| DCAPI1055 |
Iloperidone (Fanapt) |
Iloperidone (Fanapt) |
|
| DC11422 |
Lumateperone Tosylate
Featured
|
Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM). |
|
| DC11323 |
LY354740 |
LY354740 is an agonist of the group II metabotropic glutamate receptor (mGluR) subtypes mGluR2 and mGluR3 (Kis = 99 and 94 nM, respectively). |
|
| DC7192 |
LY-404039
Featured
|
LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor. |
|
| DC7459 |
LY500307 |
LY500307 is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. |
|
| DC9993 |
MK-8998
Featured
|
MK-8998 is a novel bioactive compound for the treament of psychiatric disease. |
|
| DC10455 |
NE-100
Featured
|
NE100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, |
|
| DC8583 |
Asenapine Maleate
Featured
|
Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8 |
|
| DC11937 |
PF 05180999
Featured
|
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
|
| DC7201 |
PF-2545920(MP-10)
Featured
|
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
|
| DC7268 |
Risperidone(R 64 766) |
Risperidone(R 64 766) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM). |
|
| DC7945 |
TAK-063
Featured
|
TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. |
|
| DC9157 |
Trifluoperazine dihydrochloride |
Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. |
|
| DCAPI1039 |
Ziprasidone HCl |
Ziprasidone HCl |
|
