| DC11019 |
ASP3662
Featured
|
ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
|
| DCS-019 |
(-)-Huperzine A |
>98%,Standard References |
|
| DCJ-030 |
Galanthamine |
>98%,Standard References |
|
| DCL-027 |
Lipoic acid
Featured
|
Lipoic acid is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.
Lipoic acid shows a favorable selectivity profile on Nav, Cav, SK, and IK channels.
Lipoic acid causes distinct activation from a concentration of 0.3 and 10 µM Lipoic acid left-shifted the voltage activation curve by 60 mV.
Lipoic acid reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. |
|
| DCL-011 |
Capsaicin |
>98%,Standard References |
|
| DC11936 |
TAK-915 |
A highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
|
| DC11523 |
Landipirdine |
A novel 5-HT receptor antagonist for the treatment of Parkinson's disease.. |
|
| DC11674 |
PF-DcpSi |
A potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM. |
|
| DC11514 |
Atogepant |
A potent, selective and orally available CGRP receptor antagonist for the prevention of migraine.
Migraine. |
|
| DC11838 |
Org 25935 |
A potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM. |
|
| DC11895 |
Foliglurax hydrochloride |
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC11894 |
Foliglurax |
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC11491 |
A-1048400 |
A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
|
| DC11490 |
A-317567 |
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
|
| DC7351 |
A-740003 |
A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
|
| DC9706 |
ABT-639
Featured
|
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 = 8 μM). |
|
| DC11155 |
ABX-1431
Featured
|
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
|
| DC11183 |
ABX-1431 hydrochloride
Featured
|
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
|
| DC9900 |
Acetaminophen
Featured
|
Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. |
|
| DC11439 |
Nemorexant
Featured
|
ACT-541468 is a dual orexin receptor antagonist. |
|
| DC8476 |
ACY-738
Featured
|
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 with IC50 values of 1.7 nM, with respective average selectivity over class I HDACs being 100-fold. |
|
| DC7050 |
ADL5859 HCl
Featured
|
ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid |
|
| DC3171 |
Agomelatine |
Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
|
| DC7692 |
Almorexant HCl (Act-078573)
Featured
|
Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
|
| DC11301 |
ALZ-801
Featured
|
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. |
|
| DC11239 |
AMG-333
Featured
|
AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. |
|
| DC11878 |
AMG-579 |
AMG-579 is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM. |
|
| DC10132 |
AMG9810
Featured
|
AMG9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). |
|
| DC11428 |
Olorinab |
APD-371 (APD371, Olorinab) is a potent, selective and orally available CB2 agonist with EC50 of 6.2 nM; displays no activity against CB1 receptors (EC50>10 uM); exhibits activity in rat model of osteoarthritis pain. |
|
| DC8998 |
Atipamezole HCl |
Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor. |
|
