| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11019 | ASP3662 Featured | ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
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| DC11206 | HSD-016 Featured | HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively. |
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| DC11207 | INCB13739 Featured | INCB13739 (INCB-13739) is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors.. |
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| DC10832 | (E/Z)-4-hydroxy Tamoxifen Featured | (E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen that is formed by the action of cytochrome P450 2D6 in human liver. |
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| DC9584 | (R)-(-)-Rolipram | (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4. |
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| DC9450 | (R)-Baclofen | (R)-Baclofen(STX209) is a selective GABAB receptor agonist. |
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| DC9137 | Timolol Maleate Featured | (S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively). |
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| DCS-019 | (-)-Huperzine A | >98%,Standard References |
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| DCC-073 | Gossypol-acetic acid | >98%,Standard References |
|
| DCF-001 | Tetrandrine | >98%,Standard References |
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| DCE-016 | Chenodeoxycholic acid | >98%,Standard References |
|
| DCL-047 | Sulforaphane | >98%,Standard References |
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| DCS-091 | Cephalomannine | >98%,Standard References |
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| DCC-002 | Vinblastine | >98%,Standard References |
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| DCJ-030 | Galanthamine | >98%,Standard References |
|
| DCL-027 | Lipoic acid Featured | Lipoic acid is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. Lipoic acid shows a favorable selectivity profile on Nav, Cav, SK, and IK channels. Lipoic acid causes distinct activation from a concentration of 0.3 and 10 µM Lipoic acid left-shifted the voltage activation curve by 60 mV. Lipoic acid reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions. |
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| DCL-011 | Capsaicin | >98%,Standard References |
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| DC9482 | 17-AAG Featured | 17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
|
| DCAPI1409 | Maxacalcitol | 22-Oxacalcitriol is a Vitamin D3 analog which is Non-calcemic as well as a VDR ligand. 22-Oxacalcitriol has been shown to decrease parathyroid hormone (PTH) mRNA expression in vitro. Additionally has been noted to exhibit similar effects to calcitriol in |
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| DCAPI1525 | 5-Azacytidine Featured | 5-Azacytidine is a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (Dnmt), forming covalent adducts with cellular DNMT1 depleting enzyme activity. 5-Azacytidine also improves t |
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| DC8944 | 5-Fluorouracil | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
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| DC11932 | GPX-150 | A doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
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| DC11531 | Teslexivir | A first-in-class, small molecule protein-protein inhibitor of the interaction between the E1 and E2 proteins of HPV types 6 and 11. |
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| DC12012 | PD 404182 Featured | PD 404182 is a high affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria. |
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| DC11861 | TAK-441 | A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays. |
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| DC11936 | TAK-915 | A highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
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| DC11522 | Imarikiren hydrochloride | A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay. |
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| DC11823 | BMS-929075 | A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively. |
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| DC11933 | RX 871024 | A imidazoline compound that stimulate insulin release by inhibition of ATP-dependent K+ channels and inducing of Ca2+ mobilization in mouse pancreatic beta-cells. |
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| DC11530 | Tapinarof (Benvitimod; GSK2894512) Featured | Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice. |
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