| DC11518 |
Cavosonstat
Featured
|
Cavosonstat is a potent, orally bioavailable inhibitor of S-nitrosoglutathione reductase (GSNOR) and CFTR modulator. |
|
| DC9986 |
Acebilustat(ZK322)
Featured
|
Acebilustat(ZK322) is a potent and selective leukotriene A4 hydrolase inhibitor. |
|
| DC10459 |
BMS-986020
Featured
|
BMS-986020 is an LPA1 antagonist. |
|
| DC9278 |
CWHM-12
Featured
|
CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1. |
|
| DC9434 |
DMP 777 |
DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
|
|
| DC11803 |
GLPG-1690(Ziritaxestat)
Featured
|
GLPG-1690 is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM. |
|
| DC10753 |
GLPG-1837(ABBV-974)
Featured
|
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator. |
|
| DC11678 |
GLPG-2222 |
GLPG-2222 (ABBV-2222, Galicaftor) is a novel potent and efficacious CFTR corrector with EC50 of 5 nM. |
|
| DC4128 |
Ivacaftor (VX-770)
Featured
|
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
|
| DC11096 |
Olacaftor |
Olacaftor (VX-440, VX440) is a next-generation CFTR corrector, showsthe potential to enhance the amount of CFTR protein at the cell’s surface and for treatment of cystic fibrosis.. |
|
| DC11100 |
PBI-4050 sodium |
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
|
| DC11099 |
PBI-4050 |
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
|
| DC10390 |
TD139
Featured
|
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM. |
|
| DC1059 |
Lumacaftor(vx-809，vx809)
Featured
|
VX-809 is a CFTR modulator with EC50 of 0.1 μM. |
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