| DC10812 |
ACP-105
Featured
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ACP-105 is a novel non-steroidal SARM (Selective Androgen Receptor Modulator). |
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| DC8122 |
Andarine (GTX-007,S-4)
Featured
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GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. |
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| DC7064 |
Apalutamide（ARN509）
Featured
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ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment. |
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| DC4169 |
ASC-J9 |
ASC-J9, is antitumor agent. ASC-J9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. |
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| DC5013 |
AZD3514 |
AZD3514 is a potent and oral androgen receptor with Ki of 2.2 μM and has ability of reducing AR protein expression. |
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| DC9547 |
Boldenone Undecylenate |
Boldenone undecylenate(Equipoise) is a synthetic steroid which has a similar effect as the natural steroid testosterone; it is frequently used in veterinary medicine, though it is also used in humans.
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| DC4160 |
CB-03-01
Featured
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CB-03-01 is a steroidal ester, androgen antagonist derived from 11-deoxycortisone, which tightly mimics the profile of an ideal anti-androgen for topical use. |
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| DC8856 |
EPI-001
Featured
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EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ∼6 μM and a selective PPAR-gamma modulator |
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| DC9738 |
GSK2881078
Featured
|
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness. |
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| DC7633 |
Ligandrol (VK5211, LGD-4033)
Featured
|
Ligandrol (LGD-4033) is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity. |
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| DC5069 |
Enzalutamide (MDV3100)
Featured
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MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
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| DC9347 |
N-desmethyl Enzalutamide
Featured
|
N-desmethyl Enzalutamide(N-desmethyl MDV3100) is a major metabolite of Enzalutamide, Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.
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| DC8700 |
ODM-201(Darolutamide)
Featured
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ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells. |
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| DC8690 |
ORM-15341(Ketodarolutamide)
Featured
|
ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct. |
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| DC8248 |
Ostarine(MK-2286)
Featured
|
Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism. |
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| DC9657 |
RAD140
Featured
|
RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). |
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| DC10993 |
RD162
Featured
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RD162 is a second-generation, orally available antiandrogen that binds to androgen receptor (AR) with IC50 of 30.9 nM. |
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| DC4163 |
RU58841
Featured
|
RU58841 is a nonsteroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) comparable to hydroxyflutamide. |
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| DC10811 |
S23
Featured
|
S23 is a novel Selective Androgen Receptor Modulator(SARM) |
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| DC12102 |
UT-155
Featured
|
UT-155 is a selective androgen receptor (AR) antagonist, with a Ki of 267 nM for AR-RBD. |
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| DC11131 |
Leelamine hydrochloride |
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| DC28811 |
N-Desmethyl Apalutamide |
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration. |
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| DC28928 |
SK33 |
SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity. |
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| DC28943 |
11-Ketodihydrotestosterone |
11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells. |
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| DC40171 |
(R)-UT-155 |
(R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer. |
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| DC40448 |
Androgen receptor antagonist 1 |
Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively. |
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| DC41093 |
Apalutamide D4 |
Apalutamide D4 (ARN-509 D4) is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM. |
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| DC41259 |
Bromopropylate |
Bromopropylate is a pesticide with moderate anti-androgenic activities. |
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| DC42465 |
ABM-14 |
ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR。
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| DC42525 |
(R)-Bicalutamide |
(R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with an antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.
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