Cat. No. | Product name | CAS No. |
DC7736 |
6H05
Featured
6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C). |
1469338-01-9 |
DC10738 |
ARS-1323
Featured
ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
1698024-73-5 |
DC10725 |
ARS-1620
Featured
ARS-1620 is a covalent compound with high potency and selectivity for KRAS-G12C. |
1698055-85-4 |
DC12031 |
ARS-1630
Featured
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
1698055-86-5 |
DC8816 |
ARS-853
Featured
ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation. |
1629268-00-3 |
DC11240 |
KBFM123
KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM). |
1090346-46-5 |
DC11223 |
KRAS inhibitor C6ME
KRAS inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro.. |
|
DC11222 |
KRAS inhibitor Cmpd2
KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro. |
|
DC7793 |
K RAS INHIBITOR-12
Featured
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
1469337-95-8 |
DC9906 |
K-Ras-IN-1
Featured
K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. |
84783-01-7 |
DC7467 |
ML-098
Featured
ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). |
878978-76-8 |
DC7963 |
NSC-23766 free base
Featured
NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA. |
733767-34-5 |
DC8725 |
NSC 23766
Featured
NSC 23766 is a specific inhibitor of the binding and activation of Rac GTPase. |
1177865-17-6 |
DC10199 |
Pan-RAS-IN-1
Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors. |
1835283-94-7 |
DC11216 |
RAS inhibitor Abd-7
RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling. |
2351843-48-4 |
DC10949 |
RasGRP3 ligand 96
Featured
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively. |
2229068-13-5 |
DC11034 |
SOS1 activator 17
SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro. |
2228955-02-8 |
DC7344 |
ZCL 278
Featured
ZCL278 is a Cdc42 small molecule modulator that directly binds to Cdc42 (Kd=11.4 uM) and inhibits Cdc42-intersectin interaction. |
587841-73-4 |
DC26136 |
MRTX849(Adagrasib)
Featured
MRTX849(Adagrasib) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. MRTX849 covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bou |
2326521-71-3 |
DC28559 |
RAS GTPase inhibitor 1
RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells. |
2252242-32-1 |
DC39083 |
BI-3406(SOS1-IN-2)
Featured
BI-3406 (compound I-6) is a potent, selective and orally active inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with IC50 of 6 nM. BI-3406 reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 exhib |
2230836-55-0 |
DC40333 |
APS6-45
Featured
APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity. |
2188236-41-9 |