Cat. No. | Product name | CAS No. |
DC11488 |
USP7-IN-4
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays. |
2196243-57-7 |
DC11553 |
FT-827
A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain). |
1959537-86-0 |
DC10838 |
F1063-0967
Featured
F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. |
613225-56-2 |
DC11554 |
FT-671
Featured
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain). |
1959551-26-8 |
DC12495 |
GNE-6640
Featured
GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM). |
2009273-67-8 |
DC11555 |
GNE-6776
Featured
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM . |
2009273-71-4 |
DC12049 |
GSK2643943A
Featured
GSK2643943A is a potent USP20 inhibitor with IC50 = 160 nM. |
|
DC10354 |
HBX 19818
Featured
HBX 19818 is a selective USP7 inhibitor with IC50 of 28.1 uM . |
1426944-49-1 |
DC7610 |
LDN-57444
Featured
LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
668467-91-2 |
DC10917 |
MF-094
Featured
MF-094 (MF094) is a potent, highly selective inhibitor of ubiquitin specific protease 30 (USP30) with IC50 of 0.12 uM, demonstrates <30% inhibitory activity for a panel of 22 USPs assays at 10 uM. |
2241025-68-1 |
DC7468 |
ML-323
Featured
ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. |
1572414-83-5 |
DC10091 |
ML364
Featured
ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G. |
1991986-30-1 |
DC10001 |
NSC632839
Featured
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 μM, 37±1 μM, and 9.8±1.8 μM, respectively. |
157654-67-6 |
DC8319 |
Spautin 1
Featured
Spautin 1 is an inhibitor of autophagy; inhibits USP10 and USP13 activity (IC50 values are 0.6 and 0.7 μM respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. |
1262888-28-7 |
DC10298 |
Ubiquitin Isopeptidase Inhibitor I, G5
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
108477-18-5 |
DC11509 |
USP25 and 28 inhibitor AZ-2
USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively. |
2165322-95-0 |
DC7525 |
USP7-USP47 inhibitor
USP7/USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 uM(USP7) and 1.0 uM(USP47). |
1247825-37-1 |
DC10642 |
VLX1570
VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro. |
1431280-51-1 |
DC11876 |
XL 188
XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively. |
|
DC11506 |
USP25 and 28 inhibitor AZ-1
Featured
USP25 and 28 inhibitor AZ-1 (AZ1) is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.7/0.6 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines. |
2165322-94-9 |
DC28551 |
USP7-IN-5
USP7-IN-5 is a potent ubiquitin specific protease 7 (USP7) inhibitor extracted from patent WO2017212012A1, example 40, has an IC50 of 49.9 nM. |
2166599-74-0 |
DC28552 |
USP7-IN-6
USP7-IN-6 is a potent ubiquitin specific protease 7 (USP7) inhibitor, extracted from patent WO2017212010A1, example 25, has an IC50 of 6.8 nM. |
2166586-47-4 |