Home > Inhibitors & Agonists > GPCR > Free Fatty Acid Receptor (FFAR)
Cat. No. Product name CAS No.
DC11994 ZQ-16

A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.

376616-73-8
DC11697 AM-1638

A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.

1142214-62-7
DC11683 LY2881835

A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.

1292290-38-0
DC11682 LY2922083

A potent, selective, orally available GPR40 agonist with EC50 of 9 nM.

1309435-78-6
DC11680 LY3104607

A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.

1795232-22-2
DC11623 GPR120 agonist 4x

A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.

1628448-77-0
DC7867 AMG-837 Featured

AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

865231-46-5
DC10554 DC260126 Featured

DC260126, a small-molecule antagonist of GPR40.

346692-04-4
DC8593 GPR120 Compound A Featured

GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1).

1599477-75-4
DC11143 GPR40 AgoPAM AP5

GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).

1623194-37-5
DC8577 FFA4 (GPR120) agonist GSK137647A Featured

GSK-137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3.

349085-82-1
DC9458 GW-1100

GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.

306974-70-9
DC11681 LY2922470

LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM.

1423018-12-5
DC11100 PBI-4050 sodium

PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

1254472-97-3
DC11099 PBI-4050

PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

1002101-19-0
DC5073 TAK-875(Fasiglifam) Featured

TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM.

1000413-72-8
DC9981 TUG891 Featured

TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively.

1374516-07-0
DC70406 FFAR2 agonist 58

FFA2R agonist 58 is a potent, allosteric FFAR2 (GPR43) agonist/modulator.FFA2R agonist 58 functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.FFA2R agonist 58 lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.FFA2R agonist 58 significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.

1208552-99-1
DC70601 MK-8666

MK-8666 is a selective partial GPR40 agonist developed for the treatment of type 2 diabetes mellitus.

1544739-76-5
DC71955 Xelaglifam

Xelaglifam is a potent GPR40 agonist. Antihyperglycaemic activity.

2230597-99-4
DC72259 BI-2081

BI-2081 is a GPR40 (FFAR1) partial agonist (EC50: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2.

1458656-71-7
DC72260 TP-051

TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes.

858097-86-6
DC72534 TUG-469

TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.

1236109-67-3
DC72535 TUG-499 Featured

TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes.

1206629-08-4
DC73432 2CTAP

2CTAP is a small molecule inverse agonist of FFA2 receptor signalling, inhibits constitutive Ca2+ levels, antagonised acetate-induced pERK1/2 and prevents damage following IRI, has no effect on cAMP.

1229382-66-4
DC73433 AZ13595491

AZ13595491 (AZ491) is a potent, selective G-protein-coupled receptor GPR120 (FFAR4) agonist with IC50 of 0.74/1.0 uM for huamn/mouse GPR120, respectively.

2095484-93-6
DC73434 AZ423

AZ423 (AZ13595423, AZ-423) is a potent, selective G-protein-coupled receptor GPR120 (FFAR4) agonist with IC50 of 0.36/0.51 uM for huamn/mouse GPR120, respectively.

2095488-15-4
DC73435 CPL207280

CPL207280 (CPL 207280) is a novel potent, selective GPR40/FFA1 agonist with EC50 of 80 nM in a Ca2+ influx assay, shows greater potency than fasiglifam (EC50=270 nM).

2361497-72-3
DC73436 MK-2305

MK-2305 (MK2305) is a potent and selective partial GPR40 (FFAR1) agonist with EC50 of 6 nM (rat GPR40), stimulates glucose stimulated insulin secretion (GSIS).

2101206-49-7
DC73437 Phenylacetamide 2

Phenylacetamide 2 (FFA2 allosteric agonist 2) is a potent, specific and allosteric agonist of FFA2 (GPR43) with cAMP IC50 of 0.48 and 0.66 uM for hFFA2 and mFFA2, respectively.

1103523-25-6
DC73438 TUG-2304

TUG-2304 (TUG2304) is a highly potent FFA2 (GPR43) antagonist with IC50 of 3-4 nM in both cAMP and GTPγS assays.

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