Cat. No. | Product name | CAS No. |
DC11994 |
ZQ-16
A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM. |
376616-73-8 |
DC11697 |
AM-1638
A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM. |
1142214-62-7 |
DC11683 |
LY2881835
A potent, selective, orally available GPR40 agonist with EC50 of 8 nM. |
1292290-38-0 |
DC11682 |
LY2922083
A potent, selective, orally available GPR40 agonist with EC50 of 9 nM. |
1309435-78-6 |
DC11680 |
LY3104607
A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM. |
1795232-22-2 |
DC11623 |
GPR120 agonist 4x
A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays. |
1628448-77-0 |
DC7867 |
AMG-837
Featured
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
865231-46-5 |
DC10554 |
DC260126
Featured
DC260126, a small-molecule antagonist of GPR40. |
346692-04-4 |
DC8593 |
GPR120 Compound A
Featured
GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). |
1599477-75-4 |
DC11143 |
GPR40 AgoPAM AP5
GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM). |
1623194-37-5 |
DC8577 |
FFA4 (GPR120) agonist GSK137647A
Featured
GSK-137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. |
349085-82-1 |
DC9458 |
GW-1100
GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99. |
306974-70-9 |
DC11681 |
LY2922470
LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM. |
1423018-12-5 |
DC11100 |
PBI-4050 sodium
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
1254472-97-3 |
DC11099 |
PBI-4050
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
1002101-19-0 |
DC5073 |
TAK-875(Fasiglifam)
Featured
TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM. |
1000413-72-8 |
DC9981 |
TUG891
Featured
TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. |
1374516-07-0 |
DC70406 |
FFAR2 agonist 58
FFA2R agonist 58 is a potent, allosteric FFAR2 (GPR43) agonist/modulator.FFA2R agonist 58 functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.FFA2R agonist 58 lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.FFA2R agonist 58 significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells. |
1208552-99-1 |
DC70601 |
MK-8666
MK-8666 is a selective partial GPR40 agonist developed for the treatment of type 2 diabetes mellitus. |
1544739-76-5 |
DC71955 |
Xelaglifam
Xelaglifam is a potent GPR40 agonist. Antihyperglycaemic activity. |
2230597-99-4 |
DC72259 |
BI-2081
BI-2081 is a GPR40 (FFAR1) partial agonist (EC50: 4 nM). BI-2081 induces glucose depending insulin secretion and reduces the plasma glucose concentration. BI-2081 can be used in the research of metabolic diseases, in particular diabetes type 2. |
1458656-71-7 |
DC72260 |
TP-051
TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes. |
858097-86-6 |