| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9964 | BEC hydrochloride Featured | BEC is a boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginase I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). |
|
| DC11709 | CB-1158 | CB-1158 (INCB-01158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM. |
|
| DC40170 | nor-NOHA monoacetate | nor-NOHA (Nω-Hydroxy-nor-L-arginine) monoacetate is a potent and selective arginase inhibitor. nor-NOHA monoacetate inhibits rat liver arginase with a Ki of 0.5 μM. |
|
| DC48211 | ARG1-IN-1 | ARG1-IN-1 is a human arginase 1 inhibitor with an IC50 of 29 nM. |
|
| DC73714 | AZD0011 | AZD0011 (AZD-0011) a novel peptidic boronic acid prodrug of AZD0011-PL, highly potent and orally available Arginase (ARG) inhibitor with IC50 of 404/308 nM for ARG1/2, respectively. |
|
| DC73715 | AZD0011-PL | AZD0011-PL is a highly potent Arginase (ARG) inhibitor with IC50 of 7/15 nM for ARG1/2, respectively. |
|
| DC74620 | OATD-02 | OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC50s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study. |
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