| DC7818 |
(-)Blebbistatin
Featured
|
(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. |
|
| DCS-091 |
Cephalomannine |
>98%,Standard References |
|
| DCC-002 |
Vinblastine |
>98%,Standard References |
|
| DCQ-004 |
4'-Demethylepipodophyllotoxin |
>98%,Standard References |
|
| DC11928 |
MPT0B002 |
A novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells. |
|
| DC11935 |
PBOX-15 |
A novel microtubule targeting agent that induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple cancer cells. |
|
| DC11636 |
HMCEF |
A novel P-selectin inhibitor that directly binds to P-selectin. |
|
| DC11694 |
STK899704 |
A novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM. |
|
| DC7353 |
ABT-751(E 7010)
Featured
|
ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. |
|
| DC9487 |
Arg-Gly-Asp-Ser
Featured
|
Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS |
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|
| DC12274 |
AZ82 |
AZ82 is a selective HSET/KIFC1 inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. |
|
| DC11178 |
BIO1211 |
BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1. |
|
| DC4186 |
Cabazitaxel |
Cabazitaxel (Jevtana, XRP6258) is a semi-synthetic derivative of a natural taxoid. |
|
| DC7386 |
CK-636
Featured
|
CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. |
|
| DC11475 |
CK-869
Featured
|
CK-869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. |
|
| DC11107 |
CKD-516 |
CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo. |
|
| DC9278 |
CWHM-12
Featured
|
CWHM-12 a novel small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8; less potency on αvβ5(IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1. |
|
| DC8055 |
Cyclo(-RGDfK)
Featured
|
cyclo(-RGDfK,-Arg-Gly-Asp-D-Phe-Lys)) is a selective αvβ3-integrin antagonist. |
|
| DC8399 |
Cyclo(RGDyK)
Featured
|
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. |
|
| DC5134 |
lexibulin (CYT997) |
CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 1/2. |
|
| DC10919 |
DRP1 inhibitor 4 |
DRP1 inhibitor 4 is a selective, small molecule inhibitor of the mammalian mitochondrial division dynamin, DRP1 with IC50 of 1.0 uM, shows no activity against OPA1 and DYN1 (IC50>100 uM).. |
|
| DC11177 |
DS-70 |
DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity. |
|
| DC10953 |
DZ-2384 |
DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types. |
|
| DC9270 |
Eg5 Inhibitor III（Dimethylenastron）
Featured
|
Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound that acts as a strong, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5. |
|
| DC4198 |
Epothilone B
Featured
|
Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
|
| DCAPI1539 |
Eribulin Mesylate
Featured
|
Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven. Eribulin is also known as E7389 and ER-086526, and also carries the US NCI designation NSC-707389. It is used to treat certain patients with breast cancer and liposarcoma. |
|
| DCAPI1516 |
Eribulin |
Eribulin Mesylate (E7389 Mesylate), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules. |
|
| DC5882 |
Fosbretabulin disodium
Featured
|
Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. |
|
| DC7812 |
GSK923295
Featured
|
GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. |
|
| DC5107 |
SB-715992 (Ispinesib)
Featured
|
Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. |
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