| DC8476 |
ACY-738
Featured
|
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 with IC50 values of 1.7 nM, with respective average selectivity over class I HDACs being 100-fold. |
|
| DC3171 |
Agomelatine |
Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
|
| DC9765 |
CERC-501(LY-2456302,Aticaprant)
Featured
|
CERC-501(LY-2456302) is a potent, selective antagonist of the kappa opioid receptor (KOR) (Ki = 0.81 nM vs. 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR), respectively. |
|
| DC12493 |
HT-2157(SNAP37889)
Featured
|
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). |
|
| DC12271 |
JNJ-54175446
Featured
|
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
|
| DC11469 |
APD125(Nelotanserin)
Featured
|
Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. |
|
| DC10394 |
Org-26576 |
Org 26576 is a AMPA receptor positive allosteric modulator. |
|
| DC9098 |
Paroxetine HCl
Featured
|
Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). |
|
| DC9513 |
Radafaxine (hydrochloride)
Featured
|
Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulat |
|
| DC8175 |
Rapastinel(GLYX-13)
Featured
|
Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site. |
|
| DC9320 |
Setiptiline (maleate) |
Setiptiline is a serotonin receptor antagonist.
|
|
| DC9319 |
Setiptiline |
Setiptiline(Org-8282) is a serotonin receptor antagonist.
|
|
| DC8824 |
Traxoprodil
Featured
|
Traxoprodil is an NMDA ε 2 (NR2B) antagonist that has been studied as an alternative to serotonin selective reuptake inhibitors. |
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