| DC11952 |
(R)-DRF053 dihydrochloride |
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
|
| DCL-046 |
Triptolide,14-deoxy-14-oxo |
>98%,Standard References |
|
| DCS-054 |
Carnosic acid |
>98%,Standard References |
|
| DC5144 |
1-Azakenpaullone
Featured
|
1-Azakenpaullone is a potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC₅₀ = 18 nM). |
|
| DC11489 |
6-alkynyl Fucose |
A fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1. |
|
| DC11861 |
TAK-441 |
A highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays. |
|
| DC11790 |
VU-WS211 |
A negative control of VU-WS113, which is a potent inhibitor of Wnt signaling with EC50 of 80 nM that selectively potentiates CK1α kinase activity.. |
|
| DC11785 |
IHR-1 |
A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay. |
|
| DC11784 |
IHR-Nac |
A novel cell permeable smoothened antagonist with IC50 of 3.1 nM in Hh-dependent Gli transcriptional activity assay. |
|
| DC11930 |
EDD3 |
A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes. |
|
| DC11827 |
9-ING-41
Featured
|
9-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor[1]. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity[2]. |
|
| DC11950 |
SR-2890
Featured
|
A potent, highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 of 4 nM for CK1δ. |
|
| DC11948 |
CK2 inhibitor D11 |
A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM. |
|
| DC11615 |
γ-secretase modulator 14a |
A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM. |
|
| DC11951 |
Bischof-5 |
A potent, specfic casein kinase 1δ (CK1δ) inhibitor with IC50 of 40 nM. |
|
| DC11949 |
SR-653234 |
A purine scaffold casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 of 160/540 nM, respectively.. |
|
| DC11299 |
ABC 1183
Featured
|
ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modu |
|
| DC10929 |
ABC99 |
ABC99 is a potent, selective inhibitor of the Wnt-deacylating enzyme serine hydrolase NOTUM with IC50 of 13 nM, shows excellent selectivity across the serine hydrolase family. |
|
| DC11886 |
Adavivint
Featured
|
Adavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro |
|
| DC8570 |
ALLO-1
Featured
|
ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM). |
|
| DC11651 |
HLY-78
Featured
|
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1]. |
|
| DC11788 |
Pyrvinium Iodide |
An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity. |
|
| DC11787 |
Pyrvinium |
An anthelmintic effective for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM, binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity. |
|
| DC11602 |
BI-2545 |
BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively. |
|
| DC8263 |
Bikinin
Featured
|
Bikinin is a strong activator of brassinosteroid (BR) signaling. |
|
| DC7663 |
BIO
Featured
|
BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor. |
|
| DC9951 |
AMBMP
Featured
|
AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer c |
|
| DC3114 |
Avagacestat (BMS-708163)
Featured
|
BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively. |
|
| DC7154 |
BMS-833923 (XL-139)
Featured
|
BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhi |
|
| DC11862 |
BMS-906024 |
BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively. |
|
