| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10209 | ALW-II-41-27 Featured | ALW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor, used for cancer treatment. |
|
| DC7473 | NVP-BHG712 Featured | NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively. |
|
| DC11073 | UniPR1331 | UniPR1331 (UniPR-1331) is a selective, orally available antagonist of Eph/ephrin interaction with pIC50 of 5.45, IC50 of 2.9 uM. |
|
| DC50113 | UniPR129 | UniPR129 is a potent but problematic Eph/ephrin antagonist. UniPR129 has the potential for the research of cancer disease. |
|
| DC72101 | BT5528 | BT5528 is a bicyclic peptide toxin conjugate, an EphA2 activator. BT5528 is made up of a bicyclic peptide and Auristatin E, is derivated from BCY6099. BT5528 shows potent anti-tumor activity without bleeding or coagulation toxicity in rats model. |
|
| DC74405 | Targefrin | Targefrin is a potent, selective antagonist targeting ligand binding domain of receptor tyrosine kinase EphA2 (EphA2-LBD), binds to EphA2-LBD with Kd of 21 nM (ITC) and shows IC50 value of 10.8 nM in biochemical assays. |
|
| DC74406 | WCDD301 | WCDD301 is a high-affinity, orally available agonist of EphA4 receptor. |
|
