Cat. No. | Product name | CAS No. |
DC7348 |
3-Methyladenine
Featured
3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM. |
5142-23-4 |
DC11631 |
INCB040093
A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM. |
1262440-25-4 |
DC11795 |
BL-140
A novel specific p110β inhibitor with IC50 of 5.74 nM. |
663620-66-4 |
DC10646 |
VPS34 inhibitor(Compound 80)
Featured
A novel VPS34 inhibitor. |
|
DC11938 |
IPI-3063
A novel, potent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays. |
1425043-73-7 |
DC11841 |
LAS191954
A potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM. |
1403947-26-1 |
DC7538 |
A66
Featured
A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms. |
1166227-08-2 |
DC8760 |
Acalisib
Featured
Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM. |
870281-34-8 |
DC8618 |
AMG-319
Featured
AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
1608125-21-8 |
DC7068 |
AS605240
AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. |
648450-29-7 |
DC10461 |
Autophinib
Featured
Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34. |
1644443-47-9 |
DC8004 |
AZD6482
Featured
AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. |
1173900-33-8 |
DC8380 |
AZD8186
Featured
AZD8186 is an inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. |
1627494-13-6 |
DC9879 |
AZD8835
Featured
AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM). |
1620576-64-8 |
DC9939 |
BAY 1082439
BAY 1082439 is a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. |
1375469-38-7 |
DC9718 |
BEBT-908(CUDC-908)
Featured
BEBT-908(CUDC-908)is a novel PI3K/HDAC inhibitor. |
1235449-52-1 |
DC3136 |
NVP-BEZ235
Featured
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
915019-65-7 |
DC5154 |
BKM120 (NVP-BKM120, Buparlisib)
Featured
BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. |
944396-07-0 |
DC5068 |
Idelalisib (CAL-101,GS-1101)
Featured
CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. |
870281-82-6 |
DC8833 |
Desmethyl VS-5584
Featured
Desmethyl VS-5584 is a PI3K/mTOR kinase inhibitor |
1246535-95-4 |
DC10103 |
ETP-46321
Featured
ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM for p110α/p110β; exhibits potency on mutated p110α(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R). |
1252594-99-2 |
DC10153 |
GDC-0077
Featured
GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I. |
2060571-02-8 |