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Cat. No.	Product Name	Field of Application
DC7348	3-Methyladenine Featured	3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.
DC11631	INCB040093	A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM.
DC11795	BL-140	A novel specific p110β inhibitor with IC50 of 5.74 nM.
DC10646	VPS34 inhibitor(Compound 80) Featured	A novel VPS34 inhibitor.
DC11938	IPI-3063	A novel, potent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays.
DC11841	LAS191954	A potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.
DC7538	A66 Featured	A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms.
DC8760	Acalisib Featured	Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.
DC8618	AMG-319 Featured	AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells
DC7068	AS605240	AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα.
DC10461	Autophinib Featured	Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.
DC8004	AZD6482 Featured	AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ.
DC8380	AZD8186 Featured	AZD8186 is an inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity.
DC9879	AZD8835 Featured	AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).
DC9939	BAY 1082439	BAY 1082439 is a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN.
DC9718	BEBT-908（CUDC-908） Featured	BEBT-908（CUDC-908）is a novel PI3K/HDAC inhibitor.
DC3136	NVP-BEZ235 Featured	BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.
DC5154	BKM120 (NVP-BKM120, Buparlisib) Featured	BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.
DC5068	Idelalisib (CAL-101,GS-1101) Featured	CAL-101 is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
DC8833	Desmethyl VS-5584 Featured	Desmethyl VS-5584 is a PI3K/mTOR kinase inhibitor
DC10103	ETP-46321 Featured	ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM for p110α/p110β; exhibits potency on mutated p110α(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R).
DC10153	GDC-0077 Featured	GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I.
DC9708	Paxalisib (GDC-0084) Featured	GDC-0084 （RG7666）, is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
DC10035	GDC-0326	GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).
DC9592	GDC-0941 (dimethanesulfonate)	GDC-0941 2 MeSO3H salt is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
DC1054	GDC0941(Pictilisib) Featured	GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively.
DC5081	Apitolisib Featured	GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selective versus others PIKK family kinases.
DC8410	GNE-317 Featured	GNE-317 is a potent, brain-penetrant PI3K inhibitor.
DC8257	GNE 477 Featured	GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.
DC8502	GNE-490 Featured	GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR.

PI3K

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