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Endocrine Disorders

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Cat. No. Product Name Field of Application Chemical Structure
DC22584 Mavorixafor(AMD-070) Featured A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.
DC11667 PF-592379 A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM.
DC5083 Cinacalcet (AMG-073) HCl Featured AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism.
DC7357 Anamorelin Featured Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.
DC11095 ATR-101 free base ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
DC8799 Avanafil(TA-1790) Featured Avanafil(TA-1790) is a potent and highly selective phosphodiesterase-5(PDE-5) inhibitor(IC50=5.2 nM) for erectile dysfunction; lower selectivity against PDE1, PDE6, and PDE11.
DC8801 Cinacalcet (AMG-073) Featured Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism.
DCAPI1241 Doxercalciferol (Hectorol) Featured Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.
DC8177 Enclomiphene citrate Featured Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes.
DC7020 Ibutamoren mesylate Featured Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue.
DC6577 Paricalcitol Paricalcitol
DC10531 PCO371 Featured PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1.
DC11664 PF-00446687 hydrochloride PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
DC11665 PF-00446687 PF-00446687(PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
DC7480 PF-3274167(cligosiban) Featured PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.
DC5901 Tadalafil Featured Tadalafil is a potent and selective inhibitor of Phosphodiesterase-5 (PDE5) This compound prevents the breakdown of phosphodiesterases, many of which are used as secondary messengers. By preventing the breakdown of these messenger molecules, tadalafil can
DC4133 Udenafil Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED)
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