| DC9137 |
Timolol Maleate
Featured
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(S)-Timolol maleate, is a potent non-selective β-adrenergic receptor antagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptor subtypes respectively). |
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| DCAPI1496 |
Ambrisentan
Featured
|
A nonpeptide endothelin ETA receptor antagonist. Antihypertensive. |
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| DC11547 |
LY-2562175
Featured
|
LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM. |
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| DC11893 |
Firibastat |
A potent, orally active, centrally acting aminopeptidase inhibitor, the prodrug of the specific and selective aminopeptidase A inhibitor EC33. |
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| DC11850 |
MK-7145 |
A potent, selective, and oral renal outer medullary potassium channel (ROMK) inhibitor with IC50 of 68 nM. |
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| DCAPI1468 |
Rosuvastatin Calcium
Featured
|
A selective, competitive inhibitor of HMG-CoA reductase, that is also antilipemic. |
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| DCAPI1495 |
Aliskiren Hemifumarate
Featured
|
Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM. |
|
| DC7804 |
Anacetrapib(MK0859)
Featured
|
Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3. |
|
| DC5114 |
Apixaban (BMS 562247-01)
Featured
|
Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. |
|
| DC9020 |
Atenolol |
Atenolol is a selective β1 receptor antagonist. |
|
| DCAPI1442 |
Atorvastatin Calcium
Featured
|
Atorvastatin Calcium |
|
| DC1094 |
Avasimibe
Featured
|
Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively. |
|
| DC8004 |
AZD6482
Featured
|
AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. |
|
| DC4210 |
Azilsartan kamedoxomil
Featured
|
Azilsartan medoxomil is an angiotensin II receptor antagonist indicated for the treatment of mild to moderate essential hypertension. |
|
| DCAPI1469 |
azilsartan
Featured
|
Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM. |
|
| DC9596 |
Azimilide (Dihydrochloride) |
Azimilide 2Hcl(NE-10064 2Hcl) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
|
|
| DC7782 |
BAY 41-2272 |
Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.. For the detailed information of BAY 41-2272, the solubility of BAY 41-2272 in water, the solubility of BAY 41-2272 in DMSO, the solubility of BAY 41-2272 in PBS buffer, the animal experiment (test) of BAY 41-2272, the cell expriment (test) of BAY 41-2272, the in vivo, in vitro and clinical trial test of BAY 41-2272, the EC50, IC50,and affinity,of BAY 41-2272, Please contact DC Chemicals. |
|
| DC7373 |
Betrixaban
Featured
|
Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a). |
|
| DCAPI1112 |
BIBR 953(Dabigatran)
Featured
|
BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. |
|
| DC1010 |
BIBR-1048 (Dabigatran etexilate)
Featured
|
BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. |
|
| DC9252 |
BMS-687453
Featured
|
BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. |
|
| DC9861 |
BMS-779788(XL-652)
Featured
|
BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders. |
|
| DC11923 |
BMS-986120
Featured
|
BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4. |
|
| DCAPI1140 |
Bumetanide
Featured
|
Bumetanide |
|
| DC9185 |
Candesartan cilexetil
Featured
|
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. |
|
| DC9142 |
Candesartan |
Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM. |
|
| DC7005 |
Cangrelor free acid
Featured
|
Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggrega |
|
| DC7990 |
Cariporide |
Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). |
|
| DC8471 |
CGS 21680 hydrochloride
Featured
|
CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM). |
|
| DC9160 |
Cilnidipine
Featured
|
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. |
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