| DC11691 |
NSC95397
Featured
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A potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively. |
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| DC12014 |
NSC117079 |
A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2. |
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| DC12013 |
NSC45586
Featured
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A selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2. |
|
| DC11638 |
BCI(NSC 150117)
Featured
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BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish. |
|
| DC8895 |
benzbromaron
Featured
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Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout. |
|
| DC10909 |
BN82002
Featured
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CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties. |
|
| DC11190 |
JTT-551 |
JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
|
| DC11191 |
JTT-551 sodium |
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
|
| DC7801 |
LB-100
Featured
|
LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
|
| DC10836 |
LMPTP inhibitor 23
Featured
|
LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
|
| DC9999 |
NQ301
Featured
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NQ301 is a selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. |
|
| DC10878 |
Raphin1
Featured
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Raphin1 is an orally available selective phosphatase inhibitor improves proteostasis and
diminishes deficits in a mouse model of Huntington’s disease. |
|
| DC11528 |
Razuprotafib
Featured
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Razuprotafib is a potent protein tyrosine phosphatase β (HPTPβ) inhibitor.. |
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| DC11549 |
Razuprotafib sodium |
Razuprotafib sodium is a potent protein tyrosine phosphatase β(HPTPβ) inhibitor.. |
|
| DC12051 |
RMC-4550
Featured
|
RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM. |
|
| DC10004 |
SHP099 free base
Featured
|
SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
|
| DC9737 |
SHP099 hydrochloride
Featured
|
SHP099 is a selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
|
| DC10088 |
TPI-1
Featured
|
TPI-1 is a potent and selective SHP-1 inhibitor effective at low nanomolar levels. |
|
| DC11021 |
KY-226
Featured
|
KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity. |
|
| DC28481 |
(E/Z)-BCI(DUSP6 inhibitor)
Featured
|
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
|
| DC28751 |
DJ001 |
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration. |
|
| DC29091 |
Microcystin-LA |
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC50s of 0.3 and 0.3 nM, respectively. |
|
| DC39105 |
SC-43
Featured
|
SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity. |
|
| DC40023 |
C2 Ceramide |
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss. |
|
| DC40042 |
ARL67156 trisodium salt hydrate |
ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase. ARL67156 trisodium salt hydrate is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12?μM, respectively. ARL67156 trisodium salt hydrate prevents in vivo the development of calcific aortic valve disease. |
|
| DC40201 |
1-Naphthyl phosphate potassium salt |
1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor. 1-Naphthyl phosphate potassium salt decreases the splice-correcting effect. |
|
| DC40293 |
Naphthol AS-BR |
Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase. |
|
| DC40334 |
PHPS1 sodium |
PHPS1 sodium is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively. |
|
| DC40863 |
AQX-435 |
AQX-435 is a potent SHIP1 phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth. |
|
| DC40991 |
3,5-Difluoro-L-tyrosine |
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs). |
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