| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC7348 | 3-Methyladenine Featured | 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM. |
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| DC11929 | ME-344 | A novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM. |
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| DC11968 | OSU-03013 | A novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 2 uM. |
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| DC11599 | PF-739 | A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers. |
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| DC11631 | INCB040093 | A novel potent, selective, orally available PI3Kδ inhibitor with IC50 of 31 nM. |
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| DC11795 | BL-140 | A novel specific p110β inhibitor with IC50 of 5.74 nM. |
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| DC10646 | VPS34 inhibitor(Compound 80) Featured | A novel VPS34 inhibitor. |
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| DC11938 | IPI-3063 | A novel, potent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays. |
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| DC11656 | AMPK-Activator-13 | A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM). |
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| DC11866 | AZD 3147 Featured | A potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM. |
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| DC11841 | LAS191954 | A potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM. |
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| DC7538 | A66 Featured | A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms. |
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| DC5163 | A-674563 Featured | A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively. |
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| DC7045 | A-769662 Featured | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity. |
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| DC7047 | AICAR (Acadesine) Featured | Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3. |
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| DC8760 | Acalisib Featured | Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM. |
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| DC7994 | Afuresertib HCl Featured | Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM). |
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| DC8411 | Afuresertib Featured | Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. |
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| DC8458 | Akt Inhibitor VIII Featured | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). |
|
| DC8695 | Akt1 and Akt2-IN-1 | Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. |
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| DC8618 | AMG-319 Featured | AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3Kδ that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits basal AKT phosphorylation, and inhibits proliferation in lymphoid tumor cells |
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| DC11130 | AMPK activator 991 | AMPK activator 991 is an allosteric AMPK activator, activates non-phosphorylated Thr172 AMPK in vitro binds to α1β1γ1 and α2β1γ1 with Kd of 0.13 and 0.17 uM, respectively.. |
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| DC11129 | AMPK activator SC4 | AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle. |
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| DC1001 | FK-506 (Tacrolimus) Featured | Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. |
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| DC8275 | Apilimod Featured | Apilimod(STA 5326) is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
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| DC7922 | APY0201 Featured | APY0201 is a potent, highly selective PIKfyve kinase inhibitor. |
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| DC9972 | ARQ-092(Miransertib) Featured | ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). |
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| DC7068 | AS605240 | AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) (IC50 = 8 nM). AS-605240 displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. |
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| DC9336 | AT7867 (dihydrochloride) | AT7867 Hcl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. |
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| DC9335 | AT7867 Featured | AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. |
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