| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11019 | ASP3662 Featured | ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
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| DC11206 | HSD-016 Featured | HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively. |
|
| DC11207 | INCB13739 Featured | INCB13739 (INCB-13739) is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors.. |
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| DC11205 | INU-101 Featured | INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively. |
|
| DC9584 | (R)-(-)-Rolipram | (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4. |
|
| DC9581 | (S)-(+)-Rolipram | (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer. |
|
| DCS-019 | (-)-Huperzine A | >98%,Standard References |
|
| DC10014 | 2-PMPA(NAALADaseinhibitor) Featured | 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. |
|
| DC7038 | A 922500 Featured | A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively. |
|
| DC11538 | AD-35 | A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates. |
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| DC11539 | AD-35 hydrochloride | A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates. |
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| DC11537 | AD-35 phosphate | A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates. |
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| DC11936 | TAK-915 | A highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
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| DC11522 | Imarikiren hydrochloride | A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay. |
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| DC11663 | GS-5759 | A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM). |
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| DC11995 | BI 703704 | A novel potent soluble guanylate cyclase (sGC) activator. |
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| DC11693 | AJS1669 sodium | A novel potent, allosteric, orally available muscle glycogen synthase 1 (GYS1) activator with EC50 of 5.2 uM. |
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| DC11692 | AJS1669 | A novel potent, allosteric, orally available muscle glycogen synthase 1 (GYS1) activator with EC50 of 5.2 uM. |
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| DC11904 | Olinciguat (IW-1701) Featured | Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay. |
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| DC11559 | PDE5-IN-6c | A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1. |
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| DC11969 | (S)-C33 | A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms. |
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| DC11777 | PDM-631 | A novel potent, selective, brain-penetrable and orally active PDE2A inhibitor with IC50 of 1.5 and 4.2 nM for human and rat PDE2A, respectively. |
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| DC11536 | Imigliptin dihydrochloride | A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM. |
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| DC11670 | MK-4409 | A potent and selective, brain penetrant FAAH inhibitor with IC50 of 11 nM. |
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| DC11901 | Leflutrozole | A potent aromatase inhibitor for the treatment of hypogonadism.. |
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| DC11883 | Adarigiline | A potent monoamine oxidase B (MAO-B) inhibitor.. |
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| DC11843 | MT-031 | A potent, brain penetrant, dual MAO-A and AChE inhibitor that shows neuroprotective effects both in vitro and in vivo. |
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| DC11624 | WIN-18446 | A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM. |
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| DC11893 | Firibastat | A potent, orally active, centrally acting aminopeptidase inhibitor, the prodrug of the specific and selective aminopeptidase A inhibitor EC33. |
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| DC11855 | CHR 2863 | A potent, orally available hydrophobic aminopeptidase inhibitor that structurally mimics the aminopeptidase inhibitor Tostedostat.. |
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