| DC11748 |
LY2033298
Featured
|
LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms. |
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| DC10293 |
AC260584 |
AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6. |
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| DC11747 |
Iperoxo |
Iperoxo is a superagonist of the muscarinic acetylcholine receptors and an OxotremorineM analog. |
|
| DC10731 |
Arecaidine but-2-ynyl ester tosylate |
Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum. |
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| DC10021 |
Batefenterol
Featured
|
Batefenterol（GSK961081，TD-5959）is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA). |
|
| DCAPI1702 |
Diphemanil methylsulfate
Featured
|
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR). |
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| DC10039 |
DREADD Agonist 21
Featured
|
DREADD agonist 21 is a potent muscarinic hM3Dq DREADD agonist (EC50 = 1.7 nM). Highly selective for hM3Dq DREADDs over endogenous hM3 receptors. |
|
| DC8912 |
Fesoterodine fumarate
Featured
|
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
|
| DC8779 |
Glycopyrrolate
Featured
|
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
|
| DC8435 |
LY2119620
Featured
|
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. |
|
| DC11111 |
PF-06764427 |
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM. |
|
| DC11116 |
PF-06827443 |
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM. |
|
| DC10012 |
Pirmenol hydrochloride
Featured
|
Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. |
|
| DC11208 |
TAK-071
Featured
|
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM. |
|
| DC7932 |
TBPB
Featured
|
TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats. |
|
| DC8813 |
TD-4208
Featured
|
TD-4208 is a potent and selective inhaled muscarinic antagonist with functional lung selectivity and long duration of action in preclinical models of bronchoconstriction. |
|
| DCAPI1449 |
Tiotropium Bromide
Featured
|
Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR M) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. This stops signaling between neurons and leads to muscle relaxation. |
|
| DCAPI1429 |
Tolterodine tartrate |
Tolterodine L-Tartrate is a muscarinic receptor antagonist that is active at all mAChR M subtypes. This compound blocks the opening of ion channels by acetylcholine, which in turn leads to muscle relaxation by blocking neuronal signaling. |
|
| DC8153 |
Umeclidinium bromide
Featured
|
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). |
|
| DC12159 |
VU 0238429
Featured
|
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. |
|
| DC12165 |
VU 0365114
Featured
|
VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM. |
|
| DC9497 |
VU0152100
Featured
|
VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.
|
|
| DC9255 |
VU0357017
Featured
|
VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15). |
|
| DC11112 |
VU0453595 |
VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1). |
|
| DC11123 |
VU0467154 |
VU0467154 (VU 0467154) is a potent, selective M4 mAChR positive allosteric modulator with EC50 of 17.7 nM. |
|
| DC11120 |
VU6004256 |
VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM). |
|
| DC9498 |
Xanomeline (oxalate) |
Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist.
|
|
| DC28123 |
Otenzepad |
Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively. |
|
| DC28321 |
Nebracetam hydrochloride |
Nebracetam hydrochloride, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration. Nebracetam hydrochloride exhibits an EC50 of 1.59 mM for elevating [Ca2+]i. |
|
| DC28388 |
PQCA |
PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively, and is inactive for other muscarinic receptors. PQCA improves cognitive performance and cerebral blood flow in rat, cynomolgus macaque, and rhesus macaque. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease. |
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