Cat. No. | Product name | CAS No. |
DCM-019 |
Propyl gallate
Featured
Propyl gallate is a common food antioxidant. Propyl gallate can inhibit the production of acrolein, glyoxal and methylglyoxal. |
121-79-9 |
DCN-005 |
Butylparaben
Featured
Butylparaben is an organic compound that has proven to be a very successful antimicrobial preservative in cosmetics, can also be used in active molecule suspensions, and as a food flavoring additive. |
94-26-8 |
DCZ-032 |
Palmitic acid
Featured
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model. |
57-10-3 |
DCY-156 |
cis-9-Octadecenoic acid
Featured
cis-9-Octadecenoic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator. |
112-80-1 |
DCD-041 |
Cholesterol
Featured
Cholesterol is a component of Lipid nanoparticles (LNPs) for RNA delivery. |
57-88-5 |
DCG-043 |
Triolein
Featured
Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities. |
122-32-7 |
DCW-004 |
Citric acid
Featured
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice. |
77-92-9 |
DCAPI1279 |
Aminocaproic acid (Amicar)
Featured
Aminocaproic acid (Amicar)is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders. |
60-32-2 |
DCAPI1060 |
L-Ascorbyl 6-palmitate
Featured
Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C. |
137-66-6 |
DC12296 |
D-(+)-Trehalose dihydrate (D-Trehalose dihydrate; α,α-Trehalose dihydrate)
Featured
D-(+)-Trehalose dihydrate can be used as a food ingredient and pharmaceutical excipient. |
6138-23-4 |
DC12145 |
DLinDMA
Featured
DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark. |
871258-12-7 |
DC12381 |
DLin-KC2-DMA
Featured
DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA. |
1190197-97-7 |
DC12235 |
LysoPC(14:0/0:0)
Featured
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. |
20559-16-4 |
DC11971 |
NAV-2729(Grassofermata)
Featured
NAV 2729 (NAV2729) is a chemical potentiator for mRNA-LNPs, increasing the delivery efficiencies of mRNA-LNPs in vitro and in vivo. NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays. |
419547-11-8 |
DC12399 |
SH-BC-893
Featured
SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve; selectively kills cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo.SH-BC-893, increases the activity of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) up to 200-fold in vitro without permeabilizing endosomes. SH-BC-893 treatment trapped endocytosed oligonucleotides within extra-lysosomal compartments thought to be more permeable due to frequent membrane fission and fusion events. Simultaneous disruption of ARF6-dependent endocytic recycling and PIKfyve-dependent lysosomal fusion was necessary and sufficient for SH-BC-893 to increase non-lysosomal oligonucleotide levels and enhance their activity. In mice, oral administration of SH-BC-893 increased ASO potency in the liver by 15-fold without toxicity. More importantly, SH-BC-893 enabled target RNA knockdown in the CNS and lungs of mice treated subcutaneously with cholesterol-functionalized duplexed oligonucleotides or unmodified ASOs, respectively. Together, these results establish the feasibility of using a small molecule that disrupts endolysosomal trafficking to improve the activity of oligonucleotides in extrahepatic tissues. |
1841409-92-4 |
DC10800 |
DLin-MC3-DMA
Featured
D-Lin-MC3-DMA(MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA. |
1224606-06-7 |
DC31000 |
LP-01
Featured
LP-01 is an ionizable cationic amino lipid (pKa = ~6.1). It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing LP-01 and encapsulating both Cas9 mRNA and modified single-guide RNA (sgRNA) for the transport protein transthyretin (Ttr) induce gene editing in liver cells in mice in a dose-dependent manner resulting in reduced serum Ttr levels for at least 12 months. |
1799316-64-5 |
DC31024 |
Lipid 5
Featured
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid[1].Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1]. |
2089251-33-0 |
DC31074 |
Isopropyl myristate
Featured
Isopropyl myristate is the ester of isopropyl alcohol and myristic acid. |
110-27-0 |
DC32182 |
DPPC
Featured
Colfosceril Palmitate, also known as 129Y-83 and DPPC, is the primary surface-active agent of natural lung surfactant and the major constituent of exogenous surface replacement preparations. Colfosceril Palmitate is used for the prophylaxis and treatment of neonatal respiratory distress syndrome. |
63-89-8 |
DC33202 |
Benzethonium Chloride
Featured
Benzethonium Chloride, also known as Hyamine, is synthetic quaternary ammonium salt that has surfactant, antiseptic, and anti-infective properties. Benzethonium Chloride is commonly used as a topical antimicrobial agent. Benzethonium chloride exhibited concentration-dependent inhibitions of HERG channel currents with IC(50) values of 4nM and 17nM, respectively, which were also voltage-dependent and use-dependent. Benzethonium Chloride shifted the channel activation I-V curves in a hyperpolarized direction for 10-15mV and accelerated channel activation and inactivation processes by 2-fold. |
121-54-0 |
DC33460 |
Calcium D-saccharate tetrahydrate
Featured
Calcium saccharate is an oxidized non-cyclic hexose sugar. It may inhibit carcinogenesis and proliferation of cancer cells. |
5793-89-5 |