| DC11301 |
ALZ-801
Featured
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ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. |
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| DC9345 |
ARN2966(2-PMAP)
Featured
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ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. |
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| DC10506 |
CPHPC(Miridesap)
Featured
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CPHPC(GSK2315698,Miridesap) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. |
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| DC8720 |
FPS-ZM1
Featured
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FPS-ZM1 is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively. |
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| DC7645 |
TH-237A
Featured
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TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. |
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| DC10217 |
TRx0237 (LMTX) mesylate
Featured
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TRx 0237 (LMTX™) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
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| DC11091 |
TRX-0237 |
TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity. |
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| DC10289 |
PE859
Featured
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PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. |
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| DC28150 |
Ro 90-7501
Featured
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Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells. |
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| DC41528 |
β-Amyloid (1-40) (TFA) |
β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease. |
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| DC41546 |
LPYFD-NH2 |
LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease. |
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| DC41547 |
LPYFD-NH2 TFA |
LPYFD-NH2 TFA, a pentapeptide, exerts some inhibitory effect on the aggregation of Aβ(1-42). LPYFD-NH2 TFA can be used for the research of Alzheimer’s disease. |
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| DC41815 |
Amyloid β-Peptide(1-43)(human) |
Amyloid β-Peptide(1-43) human, the Human β-amyloid peptide, is minor component of neuritic plaques found in brains of patients with Alzheimer's disease. |
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| DC41816 |
Amyloid β-Peptide(1-43)(human) TFA |
Amyloid β-Peptide(1-43) human TFA, the Human β-amyloid peptide, is minor component of neuritic plaques found in brains of patients with Alzheimer's disease. |
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| DC41837 |
β-Amyloid (22-35) (TFA) |
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). |
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| DC41885 |
Amyloid β-Peptide (1-37) (human) |
Amyloid β-Peptide (1-37) (human) is an amyloid β-protein fragment cleaved from amyloid precursor protein (APP). |
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| DC41886 |
AC 253 |
AC 253 is an Amylin (AMY3) receptor antagonist, inhibiting andrenomedulin-stimulated cAMP production. AC 253 protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. AC 253 blocks electrophysiological effects of Aβ. |
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| DC42446 |
TML-6 |
TML-6 inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 upregulates Apo E and suppresses NF-κB, mTOR. TML-6 increases the activity of the anti-oxidative Nrf2 gene. TML-6, an orally active curcumin derivative, has the potential for Alzheimer’s disease (AD) research. |
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| DC42447 |
gamma-Secretase Modulators |
gamma-Secretase Modulators (Amyloid-β production) is a Amyloid-β production. |
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| DC44520 |
Ezeprogind
Featured
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Ezeprogind (AZP-2006) is an orally active neurotrophic inducer. Ezeprogind targets all causes of neurodegeneration and is not only aiming at markers such as Abeta protein or tau protein. Ezeprogind is a potent neuroprotectant and can be used for the research of neurological disorders, including progressive supranuclear palsy (PSP), tauopathies, alzheimer’s and parkinson’s diseases, et al. |
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| DC44521 |
Ezeprogind disulfate
Featured
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Ezeprogind (AZP-2006) disulfate is an orally active neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration and is not only aiming at markers such as Abeta protein or tau protein. Ezeprogind disulfate is a potent neuroprotectant and can be used for the research of neurological disorders, including progressive supranuclear palsy (PSP), tauopathies, alzheimer’s and parkinson’s diseases, et al. |
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| DC44794 |
β-Amyloid (11-22) |
β-Amyloid (11-22) is a peptide fragment of β-Amyloid. |
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| DC44795 |
β-Amyloid (22-40) |
β-Amyloid (22-40) is a peptide fragment of β-Amyloid. |
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| DC44796 |
Beta-Amyloid(1-14),mouse,rat |
Beta-Amyloid(1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. |
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| DC44797 |
Cl-NQTrp |
Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein. |
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| DC45771 |
RAGE antagonist peptide TFA |
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities. |
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| DC45833 |
Aβ/tau aggregation-IN-1 |
Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier. |
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| DC46641 |
Methyl tridecanoate |
Methyl tridecanoate moderately inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE). |
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| DC46940 |
AZD4694 |
AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM). |
|
| DC47758 |
Aβ Fibrillization modulator 1 |
Aβ Fibrillization modulator 1 stabilizes Aβ monomers. |
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