| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11768 | TAM-16 | A benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13). |
|
| DC11531 | Teslexivir | A first-in-class, small molecule protein-protein inhibitor of the interaction between the E1 and E2 proteins of HPV types 6 and 11. |
|
| DC12012 | PD 404182 Featured | PD 404182 is a high affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria. |
|
| DC11823 | BMS-929075 | A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively. |
|
| DC11892 | Elsulfavirine Featured | A new-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infections, the prodrug of the active compound VM-1500A.. |
|
| DC11998 | IND-114338 | A novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc.. |
|
| DC11534 | Sudoterb Featured | A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11535 | Sudoterb dihydrchloride | A novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.. |
|
| DC11997 | IND125 | A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum. |
|
| DC11628 | HIV-1 Integrase Inhibitor 1 | A novel compound that disrupts the HIV-1 integrase LEDGF interaction. |
|
| DC11811 | SCY-078 | A novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml). |
|
| DC11854 | IDX899 | A novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively. |
|
| DC11527 | Quilseconazole Featured | A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor. |
|
| DC11877 | F3406 | A novel small-molecule arenaviruse inhibitor that exhibits strong anti-LCMV activity (IC50<1 uM) without cell toxicity. |
|
| DC11825 | MK-8876 | A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively. |
|
| DC22771 | Proxalutamide Featured | Proxalutamide (GT-0918) is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) for the potential treatment of COVID-19, prostate cancer, and breast cancer. |
|
| DC23957 | RO-9187 | A potent HCV NS5B RNA polymerase inhibitor. |
|
| DC11807 | HIV InSTI-1 | A potent HIV integrase strand transfer inhibitor (InSTIs) with IC50 of 8 nM in HIV replication assay. |
|
| DC11806 | MK-0536 | A potent HIV-1 integrase strand transfer inhibitor with IC50 of 33 nM, 9.5 nM, 40 nM, 20 nM and 237 nM for wt IN, IN Y143R, IN N155H, G118R and IN G140S-Q148H, respectively. |
|
| DC11771 | AZ-27 | A potent non-nucleoside RSV L-protein polymerase inhibitor with EC50 of 0.01 uM and 1.3 uM for RSV A2 and RSV B-WST, respectively. |
|
| DC11773 | BI Compound D | A potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 89 nM. |
|
| DC11772 | AZD-4316 | A potent respiratory syncytial virus (RSV) fusion inhibitor.. |
|
| DC11647 | JNJ-2408068 Featured | JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1]. |
|
| DC11731 | Ruzasvir | A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.. |
|
| DC11849 | DSM421 | A potent, selective P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 53 nM. |
|
| DC11871 | MMV019313 Featured | MMV019313 (MMV 019313, MMV-019313) is a potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM; shows no activity against human FPPS or GGPPS (>200 uM); exhibits distinct modes of inhibition compared with bisphosphonates, inhibits P. falciparum growth with EC50 of 268 nM, overexpression and an S228T variant of PfFPPS/GGPPS confer resistance to MMV 019313. |
|
| DC11737 | GNF-6702 | A selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM. |
|
| DC11752 | iKIX1 | A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM. |
|
| DC11774 | YM-53403 | A specific anti-respiratory syncytial virus (RSV) agent with EC50 of 0.2 uM in plaque reduction assays. |
|
| DC10797 | AB-423 Featured | AB-423 is the first-generation Hepatitis B Virus Capsid Assembly inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies. |
|
