| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11547 | LY-2562175 Featured | LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM. |
|
| DCAPI1468 | Rosuvastatin Calcium Featured | A selective, competitive inhibitor of HMG-CoA reductase, that is also antilipemic. |
|
| DCAPI1442 | Atorvastatin Calcium Featured | Atorvastatin Calcium |
|
| DC1094 | Avasimibe Featured | Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively. |
|
| DC9252 | BMS-687453 Featured | BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. |
|
| DC11098 | CKD-519 | CKD-519 (Rocacetrapib, CKD519) is a potent, selective cholesteryl ester transfer protein (CETP) inhibitor, inhibits the CETP-mediated transfer of cholesteryl ester in human serum with IC50 of 2.3 nM. |
|
| DC7125 | Evacetrapib (LY2484595) Featured | Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. |
|
| DC7422 | GSK1292263 Featured | GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. |
|
| DC4233 | GW501516 Featured | GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. |
|
| DC1009 | Laropiprant Featured | MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively. |
|
| DC10134 | Obicetrapib (AMG-899,TA-8995) Featured | Obicetrapib is a CETP inhibitor, on the elevation of high-density lipoprotein cholesterol (HDL-C) and reduction of low-density lipoprotein cholesterol (LDL-C), alone and in combination with statin therapy. |
|
| DC11360 | Pemafibrate Featured | Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis. |
|
| DC6903 | Lapaquistat Acetate (TAK-475) | Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
|
| DC7933 | Ro 48-8071 fumarate Featured | Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. |
|
| DC10700 | Seladelpar Featured | Seladelpar is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. |
|
| DCAPI1349 | Simvastatin (Zocor) Featured | Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. |
|
| DC10386 | Tenapanor Featured | Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively. |
|
| DC7040 | WAY-362450 (XL335; Turofexorate isopropyl) Featured | WAY-362450 (XL335; Turofexorate isopropyl) is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist with an EC50 of 4 nM.WAY-362450 is useful for dyslipidemia. |
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