| DC11578 |
VHL Ligand 3
Featured
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A VHL ligand for PROTAC.. |
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| DC11581 |
VHL Ligand 4 |
A VHL ligand for PROTAC.. |
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| DC11580 |
VHL-2 |
A VHL ligand for PROTAC.. |
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| DC11588 |
CC-885
Featured
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CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |
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| DC12249 |
E3 ligase Ligand 1 dihydrochloride |
E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. |
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| DC22335 |
E3 ligase Ligand 1A
Featured
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E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer.
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) |
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| DC11565 |
E3 Ligase Ligand 2
Featured
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E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
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| DC11571 |
E3 Ligase Ligand 3
Featured
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E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology. |
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| DC12028 |
MDK7526(Protein degrader 1)
Featured
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MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader. |
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| DC20512 |
VHL ligand 1
Featured
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PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.. |
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| DC11579 |
VH032
Featured
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VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.. |
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| DC26119 |
VHL ligand 2 hydrochloride
Featured
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VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. |
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| DC22337 |
E3 ligase Ligand 4(TC-E3 5032)
Featured
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E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology. |
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| DC28693 |
CC-90009
Featured
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CC-90009 is a cereblon modulator. CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. . |
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| DC39709 |
Lenalidomide-Br
Featured
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Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
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| DC40433 |
Thalidomide-O-C8-COOH |
Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs. |
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| DC40517 |
Thalidomide-O-C8-Boc |
Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs. |
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| DC41134 |
Thalidomide-5-OH
Featured
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Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs. |
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| DC42238 |
Chlorobutanol hemihydrate |
Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. |
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| DC42462 |
Lenalidomide-I |
Lenalidomide-I (Compound 72) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570. |
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| DC42463 |
Thalidomide-NH-CH2-COOH |
Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
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| DC42464 |
CRBN modulator-1
Featured
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CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM. |
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| DC42559 |
Piperidine-GNE-049-N-Boc |
Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.
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| DC51006 |
Lenalidomide-4-OH
Featured
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A Novel PROTACs building block. |
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| DC51007 |
Lenalidomide-5-aminomethyl hydrochloride
Featured
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Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC |
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| DC44854 |
β-Naphthoflavone-CH2-Br |
β-Naphthoflavone-CH2-Br (β-NF-CH2-Br) is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br can be used to synthesize the PROTAC β-NF-JQ1.
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| DC45696 |
Lenalidomide-6-F |
Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC. |
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| DC45697 |
Lenalidomide-4-aminomethyl |
Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC. |
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| DC45698 |
Lenalidomide-4-aminomethyl hydrochloride |
Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC |
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| DC45699 |
Lenalidomide-5-Br |
Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC. |
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