Cat. No. | Product name | CAS No. |
DC11578 |
VHL Ligand 3
Featured
A VHL ligand for PROTAC.. |
1448189-98-7 |
DC11581 |
VHL Ligand 4
A VHL ligand for PROTAC.. |
1631137-45-5 |
DC11580 |
VHL-2
A VHL ligand for PROTAC.. |
1631137-31-9 |
DC11588 |
CC-885
Featured
CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1. |
1010100-07-8 |
DC12249 |
E3 ligase Ligand 1 dihydrochloride
E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. |
|
DC22335 |
E3 ligase Ligand 1A
Featured
E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer. (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) |
1948273-02-6 |
DC11565 |
E3 Ligase Ligand 2
Featured
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
5054-59-1 |
DC11571 |
E3 Ligase Ligand 3
Featured
E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology. |
1061605-21-7 |
DC12028 |
MDK7526(Protein degrader 1)
Featured
MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader. |
1448189-80-7 |
DC20512 |
VHL ligand 1
Featured
PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.. |
1448297-52-6 |
DC11579 |
VH032
Featured
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.. |
1448188-62-2 |
DC26119 |
VHL ligand 2 hydrochloride
Featured
VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. |
1948273-03-7 |
DC22337 |
E3 ligase Ligand 4(TC-E3 5032)
Featured
E3 ligase Ligand 4 is a ligand of E3 ligase, used in PROTAC technology. |
835616-60-9 |
DC28693 |
CC-90009
Featured
CC-90009 is a cereblon modulator. CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. . |
1860875-51-9 |
DC39709 |
Lenalidomide-Br
Featured
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs. |
2093387-36-9 |
DC40433 |
Thalidomide-O-C8-COOH
Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs. |
2225148-51-4 |
DC40517 |
Thalidomide-O-C8-Boc
Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs. |
2225148-52-5 |
DC41134 |
Thalidomide-5-OH
Featured
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs. |
64567-60-8 |
DC42238 |
Chlorobutanol hemihydrate
Thalidomide 5-fluoride is Thalidomide-based cereblon ligand?that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1. |
835616-61-0 |
DC42462 |
Lenalidomide-I
Lenalidomide-I (Compound 72) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570. |
2207541-30-6 |
DC42463 |
Thalidomide-NH-CH2-COOH
Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032. |
927670-97-1 |
DC42464 |
CRBN modulator-1
Featured
CRBN modulator-1, a Thalidomide analog and a CRBN modulator extracted from WO2020006262A1, compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM. |
2407829-65-4 |