Cat. No. | Product name | CAS No. |
DC8567 |
3-(4-Pyridyl)
Featured
3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay |
7272-84-6 |
DC10860 |
BDP5290
Featured
BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. |
1817698-21-7 |
DC7413 |
Fasudil-HA
Featured
Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
105628-07-7 |
DC7249 |
ROCK inhibitor GSK269962A
Featured
GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. |
850664-21-0 |
DC7144 |
GSK429286A
Featured
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
864082-47-3 |
DC9614 |
Hydroxyfasudil (hydrochloride)
Featured
Hydroxyfasudil Hcl(HA1100 Hcl), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
155558-32-0 |
DC7774 |
Ripasudil(K-115)
Featured
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. |
887375-67-9 |
DC12203 |
Pentanoic acid
Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway. |
109-52-4 |
DC8185 |
Verosudil(AR-12286)
Rho-kinase (ROCK) inhibitor |
1414854-42-4 |
DC8831 |
RKI-1313
Featured
RKI-1313 is the negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer |
1342276-76-9 |
DC7269 |
RKI-1447
Featured
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2. |
1342278-01-6 |
DC8104 |
SAR407899 HCl
SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
923262-96-8 |
DC9854 |
SAR407899
Featured
SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
923359-38-0 |
DC8329 |
SLx-2119(KD-025,Belumosudil )
Featured
SLx-2119(KD-025) is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM) |
911417-87-3 |
DC7246 |
SR3677
Featured
SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. |
1072959-67-1 |
DC6902 |
Thiazovivin
Featured
Thiazovivin is a rock inhibitor and enhances fibroblast reprogramming efficiency to generate stem cells |
1226056-71-8 |
DC1028 |
Y-27632 2HCL
Featured
Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM. |
129830-38-2 |
DC10167 |
ZINC00881524
ZINC00881524 is a ROCK inhibitor. |
557782-81-7 |
DC41080 |
Chroman 1 dihydrochloride
Chroman 1 dihydrochloride is a highly potent ROCK2 inhibitor, with an IC50 of 1 nM. Chroman 1 dihydrochloride also shows inhibitory activities against MRCK, with an IC50 of 150 nM. |
|
DC41914 |
Exoenzyme C3, clostridium botulinum
Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration. |
58319-92-9 |
DC45269 |
H-1152 dihydrochloride
H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively. |
871543-07-6 |
DC45762 |
Y-27632
Featured
Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
146986-50-7 |