| DC8567 |
3-(4-Pyridyl)
Featured
|
3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay |
|
| DC10860 |
BDP5290
Featured
|
BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. |
|
| DC7413 |
Fasudil-HA
Featured
|
Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
|
| DC7249 |
ROCK inhibitor GSK269962A
Featured
|
GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. |
|
| DC7144 |
GSK429286A
Featured
|
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
|
| DC9614 |
Hydroxyfasudil (hydrochloride)
Featured
|
Hydroxyfasudil Hcl(HA1100 Hcl), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
|
|
| DC7774 |
Ripasudil(K-115)
Featured
|
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. |
|
| DC12203 |
Pentanoic acid |
Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway. |
|
| DC8185 |
Verosudil(AR-12286) |
Rho-kinase (ROCK) inhibitor |
|
| DC8831 |
RKI-1313
Featured
|
RKI-1313 is the negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer |
|
| DC7269 |
RKI-1447
Featured
|
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2. |
|
| DC8104 |
SAR407899 HCl |
SAR407899 Hcl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
|
| DC9854 |
SAR407899
Featured
|
SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
|
| DC8329 |
SLx-2119(KD-025,Belumosudil )
Featured
|
SLx-2119(KD-025) is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM) |
|
| DC7246 |
SR3677
Featured
|
SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. |
|
| DC6902 |
Thiazovivin
Featured
|
Thiazovivin is a rock inhibitor and enhances fibroblast reprogramming efficiency to generate stem cells |
|
| DC1028 |
Y-27632 2HCL
Featured
|
Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM. |
|
| DC10167 |
ZINC00881524
Featured
|
ZINC00881524 is a ROCK inhibitor. |
|
| DC41080 |
Chroman 1 dihydrochloride |
Chroman 1 dihydrochloride is a highly potent ROCK2 inhibitor, with an IC50 of 1 nM. Chroman 1 dihydrochloride also shows inhibitory activities against MRCK, with an IC50 of 150 nM. |
|
| DC41914 |
Exoenzyme C3, clostridium botulinum |
Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration. |
|
| DC45269 |
H-1152 dihydrochloride |
H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively. |
|
| DC45762 |
Y-27632
Featured
|
Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
|
| DC46167 |
Sovesudil |
Sovesudil, formally known as PHP-201, is a well-tolerated and low toxicity Rho-associated protein kinase (ROCK) inhibitor. Sovesudil can be used for the research of normal-tension glaucoma (NTG). |
|
| DC46480 |
RKI-1447 dihydrochloride |
RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis. |
|
| DC46829 |
Cotosudil |
Cotosudil is a ROCK kinase inhibitor, which can be used for glaucoma or ocular hypertension research. |
|
| DC47897 |
Sovesudil hydrochloride |
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia. |
|
| DC48904 |
ROCK2-IN-5 |
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation. |
|
| DC49565 |
AS1892802 |
AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain. |
|
| DC71495 |
WAY-624704 |
WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM. |
|
| DC72021 |
Fasudil hydrochloride semihydrate |
Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator. |
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