Cat. No. | Product name | CAS No. |
DC11927 |
iNUB
A small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM. |
352336-00-6 |
DC8658 |
AZD3264
AZD 3264 is an IkB-kinase IKK2 Inhibitor, IKK2 has been identified as one of the novel pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
1609281-86-8 |
DC11960 |
BI605906
BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
960293-88-3 |
DC7158 |
IKK-16 HCl
Featured
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
1186195-62-9 |
DC9485 |
IKK-16(free base)
Featured
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
873225-46-8 |
DC9484 |
IKK-2 inhibitor VIII
Featured
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. |
406209-26-5 |
DC7802 |
IKK(epsilon)-IN-1 (IKKE-IN-1)
Featured
IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ ΙKΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. |
1292310-49-6 |
DC8770 |
IMD-0354
Featured
IMD-0354 is a synthetic selective NF-kB inhibitor. |
978-62-1 |
DC8065 |
LY2409881 trihydrochloride
Featured
LY2409881 is a novel inhibitor of IκB kinase β (IKK2). |
946518-60-1 |
DC7969 |
PS-1145
Featured
PS-1145 has been shown to be an IKK (IKB kinase) inhibitor. |
431898-65-6 |
DC7159 |
TPCA-1
Featured
TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays>22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. |
507475-17-4 |
DC7760 |
WS3
Featured
WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation). |
1421227-52-2 |
DC7759 |
WS6
Featured
WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
1421227-53-3 |
DC8761 |
BMS-345541
Featured
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively. |
547757-23-3 |
DC28732 |
BAY-985
Featured
BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy. |
2409479-29-2 |
DC28733 |
(Rac)-BAY-985
(Rac)-BAY-985 (Compound Example 100.01) is a potent, ATP-competitive and selective TBK1 inhibitor with an IC50 of 1.5 nM. Antitumor efficacy. |
2101925-20-4 |
DC28821 |
HPN-01
HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2. |
928655-63-4 |
DC41272 |
Malachite green oxalate
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo. |
2437-29-8 |
DC44511 |
NF-κB-IN-1
Featured
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells. |
1227098-15-8 |
DC47598 |
Siegesbeckialide I
Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β. |
|
DC47599 |
Glabrescone C
Glabrescone C possesses potent anti-inflammatory activity by directly bnding to IKKα/β. |
|
DC70227 |
AZ13102909
Featured
AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.AZ909 combines with AZD6244 to enhance apoptosis in AZD6244-resistant lines in 3D culture. |
2322365-47-7 |