| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11629 | NK1-IN-9 | A potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM). |
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| DC11755 | L-732138 Featured | A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM. |
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| DC11756 | SR 140333 | A potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM. |
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| DCAPI1094 | Fosaprepitant | Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. |
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| DC4201 | Fosaprepitant dimeglumine Featured | Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. |
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| DC9519 | Maropitant | Maropitant is a neurokinin (NK1) receptor antagonist. |
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| DC9520 | NKP608 | NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. |
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| DC7245 | SB 222200 Featured | SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier. |
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| DC6906 | Aprepitant (MK-0869, L-754030) Featured | Substance P antagonists (SPA). |
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| DC8614 | Rolapitant Featured | Rolapitant (SCH619734) is a potent, selective and orally active neurokinin NK1 receptor antagonist with a Ki of 0.66 nM. |
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| DC28435 | Orvepitant maleate Featured | Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment. |
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| DC28971 | Osanetant Featured | Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia. |
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| DC41532 | MDL 29913 | MDL 29913, a cyclic pseudopeptide, is a competitive NK2 tachykinin receptor selective antagonist, with a pA2 of 8.66. |
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| DC41643 | Spantide I | Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation. |
|
| DC41644 | Spantide I TFA | Spantide I TFA, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation. |
|
| DC41647 | Hemokinin 1, human | Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia. |
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| DC41648 | Hemokinin 1, human TFA | Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia. |
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| DC41714 | GR 94800 | GR 94800 is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively. |
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| DC41715 | GR 94800 TFA | GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively. |
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| DC41716 | GR 64349 TFA | GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively. |
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| DC41717 | [Lys5,MeLeu9,Nle10]-NKA(4-10) | [Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM. |
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| DC41718 | [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA | [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM. |
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| DC42048 | Biotin-Substance P | Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). |
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| DC42311 | Neurokinin A TFA | Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues. |
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| DC42312 | Hemokinin 1 (mouse) | Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively. |
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| DC46850 | SB 218795 Featured | SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit. |
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| DC46851 | Imnopitant | Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) . |
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| DC47011 | Elinzanetant | Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia. |
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| DC48921 | Benzomalvin B | Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P. |
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| DC49648 | Imnopitant dihydrochloride | Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist. |
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