| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9482 | 17-AAG Featured | 17-AAG(NSC 330507; CP 127374) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. |
|
| DC11919 | Arimoclomol Featured | A nontoxic heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
| DC11920 | Arimoclomol maleate Featured | A nontoxic, orally active heat shock protein (HSP) coinducer and potentiator of the heat shock response. |
|
| DC12011 | KU-32 | A novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70. |
|
| DC11970 | KU675 Featured | A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively. |
|
| DC11921 | Bimoclomol | A potent heat shock protein coinducer. |
|
| DC11616 | KUNG94 | A potent, selective Grp94 inhibitor with IC50 of 8 nM. |
|
| DC11619 | KUNG29 | A potent, selective Grp94 inhibitor with Kd of 0.2 uM. |
|
| DC11618 | KUNG38 | A potent, selective Grp94 inhibitor with Kd of 0.44 uM. |
|
| DC11617 | PU-H54 Featured | PU-H54 is potent, selective Grp94 inhibitor. |
|
| DC8167 | Onalespib（AT13387,ATI13387X） Featured | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. |
|
| DC5202 | Luminespib (NVP-AUY922) Featured | AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2. |
|
| DC7086 | BIIB021(CNF2024) Featured | BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. |
|
| DC10498 | CCT251236 Featured | CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. |
|
| DC8477 | VER-49009 Featured | Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. |
|
| DC7390 | CUDC-305(DEBIO 0932) Featured | Debio 0932 ( CUDC-305 ) is a novel heat shock protein 90 (HSP90) inhibitor trong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L) . |
|
| DC7320 | Ganetespib(STA-9090) Featured | Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells. |
|
| DC7806 | Geldanamycin (NSC122750) | Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. |
|
| DC10837 | HS-10 Featured | HS-10 is a novel Hsp90 inhibitor increases the Tm of Hsp90 by 10.5°C. |
|
| DC10831 | HS-27 Featured | Hs-27 is a Novel Hsp90 Inhibitor, Exhibits Diagnostic and Therapeutic Potential in Triple Negative Breast Cancer. |
|
| DC10614 | HSF1A Featured | HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1). |
|
| DC10344 | HSP70-IN-1 Featured | HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. |
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| DC4178 | NVP-HSP990 (HSP990) Featured | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. |
|
| DC11033 | JG-231 | JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively. |
|
| DC10852 | KBU2046 Featured | KBU2046, is a small molecule that attaches to tumor proteins involved in metastasis and disables them, so they can’t travel to distant organs. |
|
| DC8247 | KNK437 Featured | KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. |
|
| DC9963 | Kribb11 Featured | KRIBB11 is a Heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). |
|
| DC7449 | KW-2478 Featured | KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2 |
|
| DC9994 | ML-346 Featured | ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay. |
|
| DC11856 | MPC-0767 | MPC-0767 (MPC0767, MPC3100 mesylate hydrate) is an L-alanine ester prodrug of MPC-3100, which is a potent, selective, orally bioavailable Hsp90 inhibitor with IC50 of 0.14 uM. |
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